PMID: 9174184Jun 1, 1997Paper

Parameters of bacterial killing and regrowth kinetics and antimicrobial effect examined in terms of area under the concentration-time curve relationships: action of ciprofloxacin against Escherichia coli in an in vitro dynamic model

Antimicrobial Agents and Chemotherapy
Alexander A FirsovG Cornaglia

Abstract

Although many parameters have been described to quantitate the killing and regrowth of bacteria, substantial shortcomings are inherent in most of them, such as low sensitivity to pharmacokinetic determinants of the antimicrobial effect, an inability to predict a total effect, insufficient robustness, and uncertain interrelations between the parameters that prevent an ultimate determination of the effect. To examine different parameters, the kinetics of killing and regrowth of Escherichia coli (MIC, 0.013 microg/ml) were studied in vitro by simulating a series of ciprofloxacin monoexponential pharmacokinetic profiles. Initial ciprofloxacin concentrations varied from 0.02 to 19.2 microg/ml, whereas the half-life of 4 h was the same in all experiments. The following parameters were calculated and estimated: the time to reduce the initial inoculum (N0) 10-, 100-, and 1,000-fold (T90%, T99%, and T99.9%, respectively), the rate constant of bacterial elimination (k(elb)), the nadir level (Nmin) in the viable count (N)-versus-time (t) curve, the time to reach Nmin (t(min)), the numbers of bacteria that survived (Ntau) by the end of the observation period (tau), the area under the bacterial killing and regrowth curve (log N(A)-t curve) ...Continue Reading

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Citations

Aug 13, 2009·The Journal of Antimicrobial Chemotherapy·Maria V SmirnovaAlexander A Firsov
Dec 23, 2009·The Journal of Antimicrobial Chemotherapy·Julia GloedeCharlotte Kloft
Jul 11, 2018·Antimicrobial Agents and Chemotherapy·Emilie RacineMaxime Gualtieri
Nov 21, 2001·Pharmacotherapy·R L White
Nov 24, 2012·The Journal of Antimicrobial Chemotherapy·Stephen H ZinnerAlexander A Firsov
Feb 15, 2001·Current Infectious Disease Reports·Alexander A. Firsov, Stephen H. Zinner
Aug 19, 2003·The Annals of Pharmacotherapy·Jerome J SchentagAlan Forrest
Aug 19, 2003·The Annals of Pharmacotherapy·George G Zhanel, Ayman M Noreddin
Jun 16, 2010·Antimicrobial Agents and Chemotherapy·Omar VesgaAndres F Zuluaga
Oct 19, 2019·The Journal of Antibiotics·Maria V GolikovaAlexander A Firsov
Jan 27, 2004·Antimicrobial Agents and Chemotherapy·Markus MuellerHartmut Derendorf
Feb 23, 2017·Antimicrobial Agents and Chemotherapy·Cédric CharrierNeil R Stokes
Oct 3, 2003·International Journal of Antimicrobial Agents·Christina GrekoBjörn Bengtsson
Jul 10, 2019·ACS Infectious Diseases·Sol R MartínezAndrés M Durantini

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