Parameters of Calcium Metabolism Fluctuated during Initiation or Changing of Antipsychotic Drugs

Psychiatry Investigation
Dragan R MilovanovicVladimir Janjic

Abstract

Serum parameters of calcium homeostasis were measured based on previously published evidence linking osteoporotic fractures and/or bone/mineral loss with antipsychotics. Prospective, four-week, time-series trial was conducted and study population consisted of patients of both genders, aged 35-85 years, admitted within the routine practice, with acute psychotic symptoms, to whom an antipsychotic drug was either introduced or substituted. Serial measurements of serum calcium, phosphorous, magnesium, 25(OH)D, parathyroid hormone, calcitonin, osteocalcin and C-telopeptide were made from patient venous blood samples. Calcium serum concentrations significantly decreased from baseline to the fourth week (2.42±0.12 vs. 2.33±0.16 mmol/L, p=0.022, n=25). The mean of all calcemia changes from the baseline was -2.6±5.7% (-24.1 to 7.7) with more decreases than increases (78 vs. 49, p=0.010) and more patents having negative sum of calcemia changes from baseline (n=28) than positive ones (n=10) (p=0.004). There were simultaneous falls of calcium and magnesium from baseline (63/15 vs. 23/26, p<0.001; OR=4.75, 95% CI 2.14-10.51), phosphorous (45/33 vs. 9/40, p<0.001; 6.06, 2.59-14.20) and 25(OH)D concentrations (57/21 vs. 13/35, p<0.001; 7.31, ...Continue Reading

References

Jan 1, 1987·Neuropsychobiology·T HiguchiT Yamauchi
Jan 1, 1980·Neuropsychobiology·P C BaastrupI Transbøl
Jul 10, 2002·Current Opinion in Nephrology and Hypertension·Thorsten Vetter, Martin J Lohse
Jun 23, 2004·Journal of Clinical Psychopharmacology·John M Davis, Nancy Chen
Apr 6, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·O SahotaD J Hosking
Sep 20, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·O Johnell, J A Kanis
Jan 20, 2007·Biochemical Society Transactions·J P H SchoeberR J M Bindels
Aug 19, 2007·Current Opinion in Nephrology and Hypertension·Chunfa Huang, R Tyler Miller
Aug 30, 2008·BMJ : British Medical Journal·Ian J Douglas, Liam Smeeth
Nov 29, 2008·BMC Clinical Pathology·Matthew T JamesBrenda R Hemmelgarn
Jan 22, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S PouwelsF de Vries
Aug 6, 2009·Pharmacoepidemiology and Drug Safety·Nenad ZornicDragan R Milovanovic
Sep 5, 2009·Journal of Bone and Mineral Metabolism·George LiamisMoses Elisaf
Feb 10, 2010·Journal of the American Medical Directors Association·Jessica J JalbertKate L Lapane
Apr 2, 2010·QJM : Monthly Journal of the Association of Physicians·G LiamisM Elisaf
Nov 26, 2010·Rheumatic Diseases Clinics of North America·Linda A Russell
Dec 7, 2010·The American Journal of Psychiatry·Dragan R MilovanovicSlobodan M Jankovic
Jan 22, 2011·Psychiatry Investigation·Tae-Young LeeHyung-Seok So
Aug 30, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Helen L Henry
Nov 23, 2011·Human Psychopharmacology·Norio SugawaraSunao Kaneko
Mar 8, 2012·Advances in Experimental Medicine and Biology·Aline Martin, L Darryl Quarles
Apr 28, 2012·International Journal of Psychiatry in Clinical Practice·Hamidreza JamilianMarzieh Hassanijirdehi
Jun 2, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jennifer L L MorganAriel D Anbar
Jun 30, 2012·Current Opinion in Psychiatry·Taishiro KishimotoChristoph U Correll
Jul 10, 2012·Molecular Pharmacology·Evangelos P DaskalopoulosMaria Konstandi
Dec 1, 2010·The EPMA Journal·Zoran Vlahovic, Dragica Radojkovic
Feb 15, 2013·Pharmacological Reports : PR·Jacek WójcikowskiWładysława A Daniel

❮ Previous
Next ❯

Citations

Jan 14, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S-H LeeC C Lee
Apr 8, 2020·Calcified Tissue International·Sharri J MortensenAra Nazarian

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here