Parameters of Memory Reconsolidation: Learning Mode Influences Likelihood of Memory Modification

Frontiers in Behavioral Neuroscience
Katharine C SimonRebecca Gomez

Abstract

When previously consolidated hippocampally dependent memory traces are reactivated they enter a vulnerable state in which they can be altered with new information, after which they must be re-consolidated in order to restabilize the trace. The existing body of literature on episodic reconsolidation largely focuses on the when and how of successful memory reactivation. What remains poorly understood is how the nature of newly presented information affects the likelihood of a vulnerable episodic memory being altered. We used our episodic memory reconsolidation paradigm to investigate if the intention to encode impacts what subsequently becomes attributed to an older, reactivated memory. Participants learned two lists of objects separated by 48 h. We integrated a modified item-list directed-forgetting paradigm into the encoding of the second object list by cueing participants to learn some of the objects intentionally (intentional learning), while other objects were presented without a cue (incidental learning). Under conditions of memory reactivation, subjects showed equal rates of memory modification for intentionally- and incidentally-learned objects. However, in the absence of reactivation we observed high misattribution rates...Continue Reading

References

Jul 1, 1993·Psychological Bulletin·M K JohnsonD S Lindsay
Mar 1, 1997·Behavioural Brain Research·J Przybyslawski, S J Sara
Jan 15, 2000·Science·J L McGaugh
Mar 22, 2001·Nature Reviews. Neuroscience·K NaderJ E LeDoux
Nov 1, 2002·Neuron·Maria H Milekic, Cristina M Alberini
Aug 20, 2003·Journal of Experimental Psychology. Learning, Memory, and Cognition·Elizabeth Ligon Bjork, Robert A Bjork
Jul 1, 1954·Journal of Experimental Psychology·L POSTMAN, L W PHILLIPS
Oct 10, 2003·Nature·Matthew P WalkerRobert Stickgold
May 21, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Akinobu SuzukiSatoshi Kida
Aug 18, 2005·The Quarterly Journal of Experimental Psychology. A, Human Experimental Psychology·Tracy L Taylor
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jacek DebiecJoseph E Ledoux
Jun 2, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jonathan L C LeeBarry J Everitt
Sep 26, 2008·Psychological Science·Jessica D PayneElizabeth A Kensinger
Feb 17, 2009·Nature Neuroscience·Merel KindtBram Vervliet
May 27, 2009·Memory·Almut HupbachLynn Nadel
Jul 31, 2009·Trends in Neurosciences·Jonathan L C Lee
Nov 26, 2009·Memory & Cognition·Kathleen L HourihanColin M MacLeod
Apr 14, 2010·Canadian Journal of Experimental Psychology = Revue Canadienne De Psychologie Expérimentale·Chelsea K QuinlanJonathan M Fawcett
Sep 21, 2010·Memory & Cognition·Jonathan M Fawcett, Tracy L Taylor
Apr 5, 2011·Cerebral Cortex·Jared M SaletinMatthew P Walker
Apr 3, 2012·Neuroscience and Biobehavioral Reviews·L NadelK Newman-Smith
Jan 11, 2013·Memory·Jonathan M FawcettLynn Nadel
May 17, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Samuel J GershmanKenneth A Norman
Nov 22, 2013·PloS One·Marieke Soeter, Merel Kindt
Nov 29, 2013·The Quarterly Journal of Experimental Psychology : QJEP·Moshe Naveh-BenjaminIris Lowenschuss-Erlich
Feb 14, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Emiliano MerloBarry J Everitt
Aug 20, 2014·Learning & Memory·Marc T J Exton-McGuinnessJonathan L C Lee
Dec 3, 2014·Behavioural Brain Research·Marc T J Exton-McGuinnessAmy C Reichelt
Jan 13, 2016·Proceedings of the National Academy of Sciences of the United States of America·Mariam Aly, Nicholas B Turk-Browne
Dec 27, 2016·Psychoneuroendocrinology·Shira Meir Drexler, Oliver T Wolf
Mar 10, 2017·Neurobiology of Learning and Memory·Katharine C N S SimonPaige E Scalf
Nov 20, 2019·Hippocampus·Natalie B BryantRebecca L Gómez

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