Parameters of pulse wave velocity: determinants and reference values assessed in the population-based study LIFE-Adult

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Daniel BaierMarkus Scholz

Abstract

Parameters of arterial stiffness such as pulse wave velocity (PWV) were recently proposed as independent risk factors of cardiovascular events. We analyse three PWV parameters in the large population-based study LIFE-Adult to identify risk factors, normal and reference values. Brachial-ankle (ba), brachial-femoral (bf) and carotid-femoral (cf) PWV assessment was performed using Vicorder device. 8509 participants aged 19-80 were analysed. PWV parameters were moderately correlated (r(ba/bf) = 0.6, r(ba/cf) = 0.46, r(bf/cf) = 0.59). Age and blood pressure are the dominant determinants of PWV parameters explaining > 18% of variability. Sex was only relevant for bfPWV and cfPWV. All further analysed cardiovascular and other risk factors are of minor importance. We provide age-dependent percentiles for the population (reference values) and for the subgroup of normotonic individuals. All percentiles show a strong increase with age. The difference between normotonic and all individuals is small for younger age groups but increases up to 1 m/s for elderly subjects. Our study confirms and further underpins the strong impact of age and blood pressure on arterial stiffness and the relatively weak contribution of other factors, supporting a...Continue Reading

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Citations

Feb 7, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Annina S VischerThilo Burkard
Mar 24, 2020·Clinical Science·Paula K Bautista-NiñoAnton J M Roks
Apr 7, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Thomas MünzelPhilipp S Wild
Mar 13, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Ignatios IkonomidisEfstathios Iliodromitis
Aug 8, 2020·The Journal of Clinical Hypertension·Anastasios KolliasGeorge S Stergiou
Oct 19, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Nima MemaranAnette Melk
Jan 5, 2021·Bioscience Reports·Luisa SchwarzmannBabett Bartling
Mar 5, 2020·Journal of the American College of Cardiology·Yao LuQingbo Xu
Feb 25, 2021·Clinics·Clara Italiano MonteiroRenata Gonçalves Mendes
Jun 16, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tiantian SangWei Zhang
Jun 15, 2021·Frontiers in Physiology·Stefan MöstlJens Tank

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Software Mentioned

R
Vicorder
gamlss
SPSS

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