Parameters of thyroid function throughout and after pregnancy in an iodine-deficient population

Thyroid : Official Journal of the American Thyroid Association
Maria José CosteiraJoana Almeida Palha

Abstract

The thyroid hormone milieu is of crucial importance for the developing fetus. Pregnancy induces physiological changes in thyroid homeostasis that are influenced by the iodine status. However, longitudinal studies addressing thyroid function during pregnancy and after delivery are still lacking in mild-to-moderate iodine-deficient populations. Here we characterize the serum parameters of thyroid function throughout pregnancy, and until 1 year after delivery, in a population of pregnant women whom we have previously reported to be iodine deficient (median urinary iodine levels below 75 microg/L). One hundred eighteen pregnant women were studied. Clinical data were recorded and serum was collected. Serum total and free thyroxine (T(4)) and triiodothyronine (T(3)), thyroid-stimulating hormone, thyroxine-binding globulin, and thyroglobulin were measured. Mean total T(4) ranged from 159 at the start of gestation to 127 nmol/L at 1 year after delivery, free T(4) from 14.2 to 17.8 pmol/L, total T(3) from 2.4 to 2.1 nmol/L, free T(3) from 6.7 pmol/L to 6.4 pmol/L, thyroid-stimulating hormone from 1.2 to 1.4 mIU/L, T(4)-binding globulin from 62.0 to 26.9 mg/L, and thyroglobulin from 11 to 10 microg/L. The pregnant women in this study had...Continue Reading

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Citations

Sep 3, 2013·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Anibal AguayoItxaso Rica
Oct 4, 2012·Animal : an International Journal of Animal Bioscience·A NuddaG Pulina
Jan 25, 2011·Thyroid : Official Journal of the American Thyroid Association·Tuija MännistöEila Suvanto
Apr 4, 2012·Thyroid : Official Journal of the American Thyroid Association·Véronique RaverotMichael Zimmermann
Mar 29, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Annie LumenJeffrey W Fisher
Dec 3, 2011·Current Opinion in Gastroenterology·David H Alpers
Apr 26, 2014·Thyroid : Official Journal of the American Thyroid Association·Zheng Feei Ma, Sheila A Skeaff
Aug 16, 2011·Current Opinion in Endocrinology, Diabetes, and Obesity·Anna Milanesi, Gregory A Brent
Apr 16, 2011·The Journal of Pediatrics·Maria José CosteiraJoana Almeida Palha
Mar 23, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Thomas A LewandowskiGail Charnley
Oct 21, 2016·Thyroid : Official Journal of the American Thyroid Association·Sarah C BathMargaret P Rayman
Feb 28, 2018·Brain and Behavior·Alexandra Miranda, Nuno Sousa
Jan 8, 2020·Thyroid : Official Journal of the American Thyroid Association·Pantea NazeriMamak Shariat
May 18, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Samira Akdader-OudahmaneDjamila Meskine

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