PMID: 15374450Mar 1, 1991Paper

Parameters to monitor aging with a possible perspective for intervention - an immunological approach

Archives of Gerontology and Geriatrics
C PieriS Damjanovich

Abstract

Reliable aging markers are very rare, which are better than the chronological age or those symptoms which have such great individual variability that their scientific value is questionable. The effect of aging on immunological behavior of human (and animal) individuals is reasonably well established. In this communication an attempt is made to find an immunological marker of aging at the level of cell surface phenomena. It was observed that ion-channel activities, having a complex regulation, loose their flexible responsiveness in lymphocyte membranes during aging. A recently discovered voltage regulation of the calcium-activated potassium channels showed a distinct change with aging of human lymphocytes. A possibility to find a better marker system in complex regulatory processes is also discussed.

References

Nov 21, 1978·Journal of Theoretical Biology·I Zs-Nagy
Aug 31, 1990·Biochemical and Biophysical Research Communications·L MátyusS Damjanovich
May 15, 1989·Biochemical and Biophysical Research Communications·C PieriS Damjanovich
Sep 21, 1989·Nature·M J Berridge, R F Irvine
Jan 1, 1989·Archives of Gerontology and Geriatrics·S DamjanovichB Somogyi
Nov 1, 1988·Quarterly Reviews of Biophysics·J MatkóS Damjanovich
Dec 1, 1958·Biochimica Et Biophysica Acta·G GARDOS

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