Parametric imaging of myocardial viability using ¹⁵O-labelled water and PET/CT: comparison with late gadolinium-enhanced CMR.

European Journal of Nuclear Medicine and Molecular Imaging
Stefan de HaanPaul Knaapen

Abstract

The perfusable tissue index (PTI) is a marker of myocardial viability. Recent technological advances have made it possible to generate parametric PTI images from a single [(15)O]H(2)O PET/CT scan. The purpose of this study was to validate these parametric PTI images. The study population comprised 46 patients with documented or suspected coronary artery disease who were studied with [(15)O]H(2)O PET and late gadolinium-enhanced (LGE) cardiac magnetic resonance imaging (CMR). Of the 736 myocardial segments included, 364 showed some degree of LGE. PTI and perfusable tissue fraction (PTF) diminished with increasing LGE. The areas under the curve of the PTI and PTF, used to predict (near) transmural LGE on CMR, were 0.86 and 0.87, respectively. Optimal sensitivity and specificity were 91 % and 73 % for PTI and 69 % and 87 % for PTF, respectively. PTI and PTF assessed with a single [(15)O]H(2)O scan can be utilized as markers of myocardial viability in patients with coronary artery disease.

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Citations

Feb 5, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Stefan A J TimmerPaul Knaapen
Nov 11, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Stefan de HaanPaul Knaapen
Feb 26, 2020·Nature Reviews. Cardiology·Marc DeweyUNKNOWN Quantitative Cardiac Imaging Study Group
Jan 5, 2014·Current Opinion in Cardiology·Benoy Nalin Shah, Roxy Senior
Jul 19, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Maria GrönmanAntti Saraste

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Methods Mentioned

BETA
imaging technique

Software Mentioned

CAPP
MASS MR Analytical Software

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