Parametric Response Mapping of Apparent Diffusion Coefficient as an Imaging Biomarker to Distinguish Pseudoprogression from True Tumor Progression in Peptide-Based Vaccine Therapy for Pediatric Diffuse Intrinsic Pontine Glioma

AJNR. American Journal of Neuroradiology
R CeschinA Panigrahy

Abstract

Immune response to cancer therapy may result in pseudoprogression, which can only be identified retrospectively and may disrupt an effective therapy. This study assesses whether serial parametric response mapping (a voxel-by-voxel method of image analysis also known as functional diffusion mapping) analysis of ADC measurements following peptide-based vaccination may help prospectively distinguish progression from pseudoprogression in pediatric patients with diffuse intrinsic pontine gliomas. From 2009 to 2012, 21 children, 4-18 years of age, with diffuse intrinsic pontine gliomas were enrolled in a serial peptide-based vaccination protocol following radiation therapy. DWI was acquired before immunotherapy and at 6-week intervals during vaccine treatment. Pseudoprogression was identified retrospectively on the basis of clinical and radiographic findings, excluding DWI. Parametric response mapping was used to analyze 96 scans, comparing ADC measures at multiple time points (from the first vaccine to up to 12 weeks after the vaccine was halted) with prevaccine baseline values. Log-transformed fractional increased ADC, fractional decreased ADC, and parametric response mapping ratio (fractional increased ADC/fractional decreased ADC...Continue Reading

References

Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Sep 1, 1996·Journal of Neuro-oncology·I E McCutcheon
Feb 25, 1999·Journal of Magnetic Resonance Imaging : JMRI·T SugaharaM Takahashi
Jun 22, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H LyngE K Rofstad
Dec 21, 2000·Journal of the National Cancer Institute·T L ChenevertB D Ross
May 24, 2003·Biometrics·John M WilliamsonGlen A Satten
Apr 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Bradford A MoffatBrian D Ross
Nov 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Daniel A HamstraBrian D Ross
Jun 8, 2006·Neoplasia : an International Journal for Oncology Research·Bradford A MoffatBrian D Ross
Aug 1, 2006·Acta Radiologica·M K BodeJ Pyhtinen
Jun 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jelena LazovicRussell E Jacobs
Dec 1, 2009·Neurosurgery Clinics of North America·Isaac YangAndrew T Parsa
Feb 27, 2010·Journal of Magnetic Resonance Imaging : JMRI·Benjamin M EllingsonKathleen M Schmainda
Mar 12, 2011·AJNR. American Journal of Neuroradiology·L C Hygino da CruzA G Sorensen
May 5, 2011·Expert Review of Neurotherapeutics·Hideho Okada, Ian F Pollack
Sep 8, 2011·Frontiers in Neuroinformatics·Krzysztof GorgolewskiSatrajit S Ghosh
Oct 8, 2011·NeuroImage·Mark JenkinsonStephen M Smith
Jan 10, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew J WieduwiltJames L Rubenstein
Dec 7, 2013·Neuro-oncology·Matthew Grech-SollarsChris A Clark

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Citations

Sep 25, 2019·Cancers·Sévérine de BruijnEva Lion
Dec 18, 2019·Expert Review of Anticancer Therapy·Norbert GalldiksKarl-Josef Langen
May 18, 2017·Journal of Immunology Research·Domenico AquinoValeria Cuccarini
Oct 10, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Roberto García-FigueirasJoan C Vilanova
Oct 17, 2020·AJNR. American Journal of Neuroradiology·P Alcaide-LeonJ E Villanueva-Meyer
May 1, 2021·International Journal of Molecular Sciences·Sanjeev ChawlaHarish Poptani

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