Paramount therapy for young and fit patients with mantle cell lymphoma: strategies for front-line therapy

Journal of Experimental & Clinical Cancer Research : CR
Haige YeMichael L Wang

Abstract

The natural history of mantle cell lymphoma (MCL) is a continuous process with the vicious cycle of remission and recurrence. Because MCL cells are most vulnerable before their exposure to therapeutic agents, front-line therapy could eliminate MCL cells at the first strike, reduce the chance for secondary resistance, and cause long-term remissions. If optimized, it could become an alternative to cure MCL. The key is the intensity of front-line therapy. Both the Nordic 2 and the MD Anderson Cancer Center HCVAD trials, with follow-up times greater than 10 years, achieved long-term survivals exceeding 10 years. But the Achilles heel in both trials were the severe toxicities, such as secondary malignancies including myelodysplastic syndromes /leukemia. Therefore, intensive therapies can act as a double-edged sword providing long term survival at the cost of severe toxicities. In our opinion, although intensive chemotherapy can cause detrimental side effects, it is indispensable given that we run the risk of sacrificing long-term survivals in these young and fit patients. We must seek for a powerful alternative at the front-line. Furthermore, minimal residual disease negativity should be the optimal therapeutic goal to achieve befor...Continue Reading

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Citations

Mar 23, 2021·Oncoimmunology·Keman ZhangReshmi Parameswaran

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Methods Mentioned

BETA
MDS
PCR
flow cytometry

Clinical Trials Mentioned

NCT02427620
NCT01527149
NCT02858258
NCT03267433
NCT02858804
NCT03282396
NCT03053024
NCT00980395
NCT02728531
NCT01484093

Software Mentioned

VR
CAP
Triangle

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