Paraneoplastic autoimmunity and small-cell lung cancer: Neurological and serological accompaniments

Thoracic Cancer
Anastasia ZekeridouVanda A Lennon

Abstract

Paraneoplastic neurological autoimmunity is often associated with small-cell lung cancer (SCLC), a highly malignant neuroendocrine tumor. Paraneoplastic autoimmunity often correlates with longer survival. We describe the paraneoplastic neurological manifestations of patients with SCLC with and without SCLC-predictive autoantibodies and the correlation between autoimmunity and survival. We reviewed the records of 116 patients (51% male) from the Mayo Clinic with histopathologically confirmed SCLC for whom stored serum was available for neural autoantibody testing. Cancer was limited stage in 41%; the median age at diagnosis was 64 years. Paraneoplastic neurological manifestations were recorded in 61% (decreasing frequency: peripheral neuropathy, dysautonomia, cognitive decline, cerebellar ataxia, neuromuscular junction disorder, seizures, cranial neuropathy, movement disorder, brainstem disorder, or myelopathy). Neural autoantibodies, some with pathogenic potential, were detected in the sera of SCLC patients with and without neurological autoimmunity. The most frequent among patients with neurological manifestations were: anti-neuronal nuclear antibody-type 1, voltage-gated calcium channel (VGCC)-N-type, VGCC-P/Q-type, glutamic ...Continue Reading

Citations

Oct 9, 2020·Journal of Clinical Neurology·Xuan SunZhenfu Wang
Feb 23, 2020·Journal of Neuroimmunology·Xinxin LiSongyan Liu
Nov 15, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Elia Sechi, Anastasia Zekeridou
Feb 15, 2021·Annals of Neurology·Divyanshu DubeySean J Pittock
May 14, 2020·Clinics in Chest Medicine·Andreas Saltos, Scott Antonia
Mar 7, 2021·Cancers·Hugo de JongeClaudia Scotti
Mar 26, 2021·Der Nervenarzt·Frederike C OertelFriedemann Paul
Apr 5, 2021·Journal of the Neurological Sciences·Cecilia Zivelonghi, Anastasia Zekeridou
Aug 8, 2021·International Journal of Molecular Sciences·Halin BarekeManuel Fuentes
Sep 3, 2021·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·César Gutiérrez PérezCarlos García Girón

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