Paraneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome Associated with Neuroendocrine Carcinoma of the Oropharynx

Internal Medicine
Junji TakasugiHideki Mochizuki

Abstract

Paraneoplastic cerebellar degeneration and Lambert-Eaton myasthenic syndrome (PCD-LEMS) are usually associated with small-cell lung carcinoma (SCLC). PCD-LEMS with extrapulmonary non-SCLC tumors; however, has not been previously reported. A 78-year-old man presented with dysarthria, dysphagia, staggering gait, and lower extremity muscle fatigue. He was diagnosed with PCD-LEMS associated with neuroendocrine carcinoma of the oropharynx, based on the histological findings of the biopsy, the existence of antibodies against P/Q-type voltage-gated calcium channels, and an incremental response of the compound muscle action potentials during repetitive nerve stimulation tests. Thus, PCD-LEMS should be included in the differential diagnosis of neurological dysfunction, even in extrapulmonary non-SCLC patients.

References

Jun 1, 1988·Brain : a Journal of Neurology·J H O'NeillJ Newsom-Davis
Jun 1, 1995·The New England Journal of Medicine·V A LennonE H Lambert
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Jan 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maarten J TitulaerJan J G M Verschuuren
Feb 9, 2013·Seminars in Oncology·James Smith, Diane Reidy-Lagunes

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Methods Mentioned

BETA
biopsy

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