Paraneoplastic necrotizing myopathy in a woman with breast cancer: a case report.

Journal of Medical Case Reports
Joana SilvestreAna Aleixo

Abstract

Paraneoplastic necrotizing myopathy is a rare disorder, described as a proximal, symmetrical, and rapidly progressing myopathy that is manifested as a paraneoplastic syndrome. Diagnosis is established via histological examination of the muscle biopsy. We present the case of a 53-year-old woman, born in Guinea-Bissau, with a history of locally advanced breast cancer, diagnosed ten months previously. The patient had experienced a progressively proximal muscle weakness of the lower extremities, which led to a total inability to walk. Upon neurological examination, the patient showed muscle weakness and atrophy in both proximal lower extremities without myalgia. Muscle strength was graded according to the Medical Research Council Scale as 2 out of 5 in the bilateral iliopsoas muscle, and 4 out of 5 in the bilateral quadriceps femoris. The deep-tendon reflexes were hypoactive. The laboratory examination showed increased values of serum creatinine kinase and myoglobin. An electromyogram showed an incomplete interference pattern during voluntary contraction in the iliopsoas and quadriceps femoris. The motor nerve conduction was 44.1 m/s and 44.3 m/s in the right and left tibial nerves, respectively, and 46.5 m/s and 46.1 m/s in the ri...Continue Reading

References

Dec 22, 1999·Acta Neuropathologica·R FazioR Nemni
Sep 20, 2001·Current Opinion in Neurology·D Hilton-Jones
Jan 25, 2003·Clinical Nuclear Medicine·Christina NanniNino Monetti
Oct 17, 2003·The New England Journal of Medicine·Robert B Darnell, Jerome B Posner
Dec 9, 2003·The Breast : Official Journal of the European Society of Mastology·G GattiA Luini
May 14, 2005·Current Opinion in Neurology·Edward J Dropcho
Oct 29, 2008·Oral Microbiology and Immunology·C KatoT Natsuno

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Citations

Dec 27, 2011·Rheumatology International·Noah SamuelsYaacov Esayag
Mar 30, 2011·Rheumatic Diseases Clinics of North America·Alan N Baer
May 9, 2014·Journal of Ovarian Research·Kyung-Jin MinJae-Kwan Lee
Dec 24, 2013·La Revue de médecine interne·E Salort-CampanaJ Pouget
Feb 20, 2015·Journal of Clinical Neuromuscular Disease·Colin QuinnNizar Souayah

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Methods Mentioned

BETA
biopsy

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