Paraneoplastic neurologic syndromes.

Current Neurology and Neuroscience Reports
Steven Vernino

Abstract

Paraneoplastic neurologic disorders (PND) are remote medical complications of cancer that cannot be attributed to direct effects of the neoplasm or its metastases. PND are uncommon, disabling syndromes that have been recognized for more than 50 years. Despite their rarity, these diseases are the subject of intensive research and clinical fascination. This review highlights notable recent publications related to PND. In recent years, the broad clinical spectrum of PND has become even more apparent. PND can affect any part of the central or peripheral nervous system and often affect multiple areas simultaneously. These disorders are often associated with neuron-specific autoantibodies in the serum and cerebrospinal fluid. In clinical practice, detection of these antibodies is crucial for the diagnosis because the neurologic symptoms usually precede the diagnosis of cancer. Recent publications have described new antibody specificities associated with PND and expand our ability to identify patients serologically. Once diagnosed, detection of cancer can be difficult, but the use of positron emission tomography has been shown to be a useful supplement to standard imaging procedures. PND are thought to be autoimmune disorders precipit...Continue Reading

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Citations

Mar 28, 2008·Current Oncology Reports·Jai GrewalArthur D Forman
Dec 25, 2010·Therapeutic Advances in Neurological Disorders·Hamid Sadeghian, Steven Vernino
Dec 12, 2012·Muscle & Nerve·Lydia Sharp, Steven Vernino

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