PMID: 8593111Nov 1, 1995Paper

Paraneoplastic pemphigus triggered by radiotherapy

The Australasian Journal of Dermatology
M S LeeR B Ravich

Abstract

Paraneoplastic pemphigus is a recently described autoimmune disease characterized by painful mucosal ulceration and polymorphous skin lesions in association with an underlying neoplasm. Distinct autoantibodies bind desmoplakin I, desmoplakin II, bullous pemphigoid antigen and an uncharacterized 190 kDa antigen. A case is presented of paraneoplastic pemphigus that developed after radiotherapy for non-Hodgkin's lymphoma in a 53 year old man. Multiple skin biopsies showed a lichenoid reaction without acantholysis. Immunofluorescence and mucosal biopsies were required to establish the correct diagnosis. Corneal opacities resembling lichenoid graft-versus-host disease and retinal haemorrhages, which developed in the patient, have not been previously documented. Despite high doses of immunosuppressive agents and plasmaphoresis, the patient eventually died from respiratory failure.

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Citations

Feb 4, 1999·Oral Oncology·G F FaviaA Piattelli
May 6, 1999·The New England Journal of Medicine·H C NousariG J Anhalt
Dec 6, 2011·Clinics in Dermatology·Suzana Ljubojevic, Jasna Lipozenčić
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Jul 5, 2012·The Australasian Journal of Dermatology·Angeline Anning Yong, Hong Liang Tey
Nov 22, 2011·International Journal of Dermatology·Talel BadriSamy Fenniche
Dec 6, 2011·Parkinsonism & Related Disorders·Matthew JonesPaul R Talbot
Dec 1, 2017·International Journal of Molecular Sciences·Giovanni PaolinoStefano Calvieri
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Jul 12, 2019·Frontiers in Immunology·Dario DidonaMichael Hertl
Sep 15, 2006·The Journal of Dermatological Treatment·Giuseppe CianchiniPietro Puddu
Mar 2, 2021·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·D Didona, M Hertl
Dec 18, 2003·Veterinary Dermatology·Michelle M Turek

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