Paraoxonase 1 and cytochrome P450 polymorphisms in susceptibility to acute organophosphorus poisoning in Egyptians

Neurotoxicology
Abeer Ahmed ZayedAly Gamaleldin AbdelAal

Abstract

Organophosphates are the basis of many insecticides, herbicides, and nerve agents. They were listed as highly acutely toxic agents. Findings in knockout mice suggest that paraoxonase 1 may modulate the toxicity resulting from exposure to organophosphorus compounds. In human, there is no enough data about genetic modulation of acute organophosphorus intoxication. CYP2D6 is involved in the metabolism of about 30% of xenobiotics. Prompt accurate management of OP acute intoxication can promote patient's survival. Forty acute organophosphorus intoxicated patients were divided according to presence of clinical toxicity manifestations and serum level of pseudo-cholinesterase into two groups of acute symptomatic and acute asymptomatic patients. A third group of 29 healthy volunteers served as control. Paraoxonase 1 Q192R and CYP2D6 G1934A polymorphisms, (QQ, QR, and RR for PON1) and (GG, GA, and AA for CYP2D6), were studied using polymerase chain reaction-restriction fragment length polymorphism technique. Serum paraoxonase 1 and pseudo-cholinesterase activities were measured spectrophotometrically. Serum pseudo-cholinesterase was significantly reduced in both acute intoxication groups compared to the controls (p=0.000). Paraoxonase 1 ...Continue Reading

References

Oct 1, 1976·Journal of Medical Genetics·J R PlayferD A Evans
Mar 30, 1984·Toxicology and Applied Pharmacology·R J NolanJ H Saunders
Apr 9, 1999·The Journal of Emergency Medicine·G M EmersonH J Mead
Feb 20, 2002·British Journal of Clinical Pharmacology·Leif BertilssonAyman Al-Shurbaji
Jul 27, 2002·Human & Experimental Toxicology·E Y SözmenM Mackness
Jan 10, 2003·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Lucio G CostaClement E Furlong
Feb 4, 2003·Pharmacogenetics·Bharti MacknessNicola Cherry
Nov 18, 2003·Naunyn-Schmiedeberg's Archives of Pharmacology·Ulrich M ZangerMichel Eichelbaum
Mar 17, 2004·Occupational Medicine·R Kamanyire, L Karalliedde
Jan 18, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lucio G CostaClement E Furlong
Jun 1, 2005·Toxicology and Applied Pharmacology·A E Rojas-GarcíaB Quintanilla-Vega
Jul 16, 2005·Advances in Therapy·Salim Satar, Gulsah Seydaoglu
Jul 22, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·N AllonE Grauer
Jul 30, 2005·Toxicology·Franz WorekLadislaus Szinicz
Jul 25, 2006·QJM : Monthly Journal of the Association of Physicians·M EddlestonN A Buckley
Nov 30, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Elaine MutchFaith M Williams
Jun 1, 2007·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·A C PoveyN M Cherry
Jul 3, 2007·Internal Medicine·Yusuf YurumezCaglar Ozdemir
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Janice E Chambers
May 1, 2010·Environmental Toxicology and Pharmacology·Milan Jokanović, Melita Kosanović
Dec 30, 2014·Turkish Journal of Medical Sciences·Şahin ÇolakLatif Duran

❮ Previous
Next ❯

Citations

Sep 17, 2019·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Zahra KhalajMansoor Salehi
Oct 26, 2018·Toxicology·Efthimios DardiotisAristidis Tsatsakis
Feb 23, 2020·Ecotoxicology and Environmental Safety·Ann-Kathrin LoerracherThomas Braunbeck

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.