Paraoxonase and arylesterase levels in autoimmune thyroid diseases

Redox Report : Communications in Free Radical Research
Hakan KorkmazErsin Akarsu

Abstract

The aim of this study was to evaluate serum paraoxonase-1 (PON1) activity and its association with oxidative stress in autoimmune thyroid disease (AITD). A total of 50 patients with AITD, including 25 with Hashimoto's thyroiditis and 25 with Graves' disease were enrolled. The control group comprised 27 healthy subjects. Blood samples were obtained in the euthyroid period and 3 months after initiation of medical treatment. Serum samples from patients with AITD and the healthy control group were analyzed for basal PON1, salt-stimulated PON1, and arylesterase (ARE) activities, along with lipid hydroperoxide (LOOH) and total free sulfhydryl (-SH) levels. Serum PON1 activities and -SH levels were significantly lower (P < 0.001, for each), whereas LOOH levels were significantly higher (P < 0.001, for each) in patients with AITD, compared to the control group. We observed no significant differences in ARE levels between the patient and healthy control groups (P > 0.05). PON1 activity was positively correlated with -SH (r = 0.522, P < 0.001) and negatively correlated with LOOH (r = -0.487, P < 0.001). PON1 phenotype distribution of the subjects was not significantly different among the three groups (P = 0.961). Serum PON1 activity is d...Continue Reading

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Citations

Oct 10, 2018·Endocrine Connections·Maria GiannakouMaria Alevizaki
Dec 4, 2019·Ophthalmic Plastic and Reconstructive Surgery·Nilay YukselHatice Pasaoglu
Dec 23, 2019·Cytogenetic and Genome Research·Brittany B HendersonRoger E Stevenson
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Sep 25, 2020·Minerva endocrinologica·Rosaria M RuggeriSebastiano Gangemi

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Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

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