Paraoxonase gene polymorphisms and stroke severity

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
L LazarosI Georgiou

Abstract

Paraoxonase (PON) is an HDL-associated enzyme that prevents low-density lipoprotein oxidation, playing a major role in the pathogenesis of atherosclerosis. PON genes polymorphisms may affect the corresponding enzyme activity. In this study, we examined the association of ischemic stroke with the three PON genes. One hundred and seventy-eight patients hospitalized for ischemic stroke and 181 age- and sex-matched healthy controls were recruited. PON1(Q/R) 192, PON1(M/L) 55, and PON2(S/C) 311 polymorphisms were analyzed. The presence of the PON2 311C allele was significantly increased in patients with severe forms of ischemic stroke according to Modified Rankin Scale (P = 0.02, odds ratio = 2.215). No significant differences in genotype and allele distribution were observed between patients and controls. The PON2 311C allele was suggested as a possible predisposing factor for severe cases of ischemic stroke. Large-scale multicenter-controlled prospective studies are warranted to further explore the effects of PON polymorphisms on stroke susceptibility and severity.

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Citations

May 29, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Hua LiuQi Wen Mu
Nov 15, 2013·Redox Report : Communications in Free Radical Research·Teresita Menini, Alejandro Gugliucci
Nov 22, 2014·Journal of Neurologic Physical Therapy : JNPT·Allon GoldbergJeffrey A Kleim

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