Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase

The Journal of Clinical Investigation
M AviramB N La Du

Abstract

HDL levels are inversely related to the risk of developing atherosclerosis. In serum, paraoxonase (PON) is associated with HDL, and was shown to inhibit LDL oxidation. Whether PON also protects HDL from oxidation is unknown, and was determined in the present study. In humans, we found serum HDL PON activity and HDL susceptibility to oxidation to be inversely correlated (r2 = 0.77, n = 15). Supplementing human HDL with purified PON inhibited copper-induced HDL oxidation in a concentration-dependent manner. Adding PON to HDL prolonged the oxidation lag phase and reduced HDL peroxide and aldehyde formation by up to 95%. This inhibitory effect was most pronounced when PON was added before oxidation initiation. When purified PON was added to whole serum, essentially all of it became HDL-associated. The PON-enriched HDL was more resistant to copper ion-induced oxidation than was control HDL. Compared with control HDL, HDL from PON-treated serum showed a 66% prolongation in the lag phase of its oxidation, and up to a 40% reduction in peroxide and aldehyde content. In contrast, in the presence of various PON inhibitors, HDL oxidation induced by either copper ions or by a free radical generating system was markedly enhanced. As PON inhi...Continue Reading

References

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·V W BowryR Stocker
Jul 29, 1991·FEBS Letters·M I MacknessP N Durrington
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·Y NaganoT Kita
Aug 1, 1990·European Heart Journal·M J MitchinsonJ H Enright
Jun 1, 1990·Biochemical Pharmacology·C V de WhalleyD S Leake
Apr 6, 1989·The New England Journal of Medicine·D SteinbergJ L Witztum
Nov 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D Reichl, N E Miller
Feb 1, 1986·The Journal of Clinical Investigation·S ParthasarathyD Steinberg
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·R C SorensonB N La Du
Jun 1, 1995·Atherosclerosis·M I Mackness, P N Durrington
Dec 8, 1994·Biochimica Et Biophysica Acta·G M Wilkins, D S Leake
Jun 30, 1994·Biochemical and Biophysical Research Communications·T HayekM Aviram
Sep 1, 1994·The Journal of Clinical Investigation·S H ZhangN Maeda
Apr 15, 1994·Biochemical and Biophysical Research Communications·D W Morel
Jan 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·R L ReddickN Maeda
Jun 1, 1993·Chemico-biological Interactions·B N La DuD Lipsig
Oct 1, 1995·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·T HayekM Aviram
Apr 1, 1996·Current Opinion in Lipidology·M I MacknessR A Hegele
Jun 1, 1996·Current Opinion in Lipidology·C L Banka
Oct 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·D N NevinJ D Brunzell
Nov 1, 1996·Nature Medicine·B N La Du
Apr 15, 1997·The Journal of Clinical Investigation·M NavabB N La Du

❮ Previous
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Citations

Nov 5, 2003·Journal of Biochemical and Molecular Toxicology·Mi-Kyung LeeMyung-Sook Choi
Sep 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Andrea CarmineLars Olson
Jan 10, 2002·Biochemical and Biophysical Research Communications·Zakaria AhmedPhilip W Connelly
Jul 28, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Keren OfekBente K Pedersen
Dec 15, 2012·Rheumatology International·Shereem Mohamed Olama, Mohammed Mohamed Elarman
Dec 6, 2006·Pflügers Archiv : European journal of physiology·Elena Thomàs-MoyàAna María Proenza
Mar 23, 2010·Pflügers Archiv : European journal of physiology·Ulrich Förstermann
Nov 3, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jelena Kotur-StevuljevićDanijela Kornic-Ristovski
Jun 1, 2005·Journal of Human Genetics·Wimon PhuntuwateBharti Mackness
Apr 25, 2012·Sleep & Breathing = Schlaf & Atmung·Hacer Kuzu OkurSebnem Yosunkaya
Apr 14, 2009·Current Atherosclerosis Reports·David Seo, Pascal Goldschmidt-Clermont
Mar 8, 2011·Current Atherosclerosis Reports·John A Farmer, Joshua Liao
Sep 4, 2009·Biological Trace Element Research·Deniz Ekinci, Sükrü Beydemir
Jun 1, 2010·Journal of Ocular Biology, Diseases, and Informatics·Subramanian BarathiVetrivel Umashankar
Dec 17, 2009·Genes & Nutrition·Raj LakshmanSamir Zakhari
Jul 2, 2010·Journal of Cardiovascular Translational Research·Shamjeet SinghPawan K Singal
May 24, 2013·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Mukund Ramchandra Mogarekar, Swati Jitendra Talekar
Jun 25, 2013·Biochemical and Biophysical Research Communications·Chi-Chih ChengShih-Lan Hsu
May 26, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Michael AviramTony Hayek
Jan 16, 2004·Experimental Gerontology·Ildiko SeresAbdelouahed Khalil
Jun 12, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Antonio F HernándezAntonio Pla
Mar 5, 2004·International Journal of Cardiology·Simone A OliveiraJoyce M Annichino-Bizzacchi
Mar 2, 2005·Journal of the American College of Surgeons·Alfredo C CordovaBauer E Sumpio
Jul 27, 1999·Chemico-biological Interactions·B N La DuT J Standiford
Mar 8, 2002·Atherosclerosis·Jerzy-Roch NoferArnold von Eckardstein
Apr 27, 1999·Atherosclerosis·M AviramP F Hollenberg
Jul 17, 1999·Atherosclerosis·O Stein, Y Stein
Sep 17, 1999·Atherosclerosis·K A RyeP J Barter
Apr 17, 2003·Life Sciences·Noriyasu TanimotoKozo Hashimoto
Aug 2, 2003·Molecular Aspects of Medicine·Norbert Leitinger
Sep 6, 2003·International Journal of Cardiology·Elif AzarsizEser Yildirim Sözmen

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