PMID: 9170151Apr 1, 1997Paper

Paraoxonase (PON1) gene in mice: sequencing, chromosomal localization and developmental expression

Pharmacogenetics
W F LiC E Furlong

Abstract

Serum paraoxonase hydrolyses the toxic metabolites of several organophosphorus insecticides, as well as the nerve agents soman and sarin. We have previously shown that elevated serum paraoxonase levels protect mice against organophosphate toxicity. In the present study, we determined the cDNA sequence and chromosomal location of the mouse paraoxonase gene, as well as its developmental expression in mice and rats. The mouse cDNA encodes a protein of 355 amino acids and shows 81% identity with the human sequence. In situ hybridization demonstrated that the mouse paraoxonase gene maps to chromosome 6, a region conserved with the paraoxonase region of chromosome 7q21-22 in humans. Serum paraoxonase activities toward three substrates, paraoxon, chlorpyrifos-oxon and diazoxon, were very low at birth and increased with age reaching adult levels at 20 days in mice and 25 days in rats. The increase of serum paraoxonase activity in developing animals correlates well with the increased resistance to organophosphate poisoning that has been reported in previous studies.

Citations

Aug 14, 1998·General Pharmacology·B MacknessM I Mackness
Jul 27, 1999·Chemico-biological Interactions·L G CostaC E Furlong
Mar 4, 2000·Environmental Health Perspectives·E M FaustmanR A Ponce
Jun 2, 2012·The Journal of Pharmacology and Experimental Therapeutics·Xingguo Cheng, Curtis D Klaassen
Jan 10, 2003·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Lucio G CostaClement E Furlong
Mar 1, 2011·Toxicology and Applied Pharmacology·Gennaro GiordanoLucio G Costa
Jan 27, 2005·Biochemical Pharmacology·Lucio G CostaClement E Furlong
Mar 23, 2004·Analytical Biochemistry·Serguei Soukharev, David J Hammond
Jan 18, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lucio G CostaClement E Furlong
Dec 13, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lucio G Costa
Apr 12, 2016·Chemico-biological Interactions·Jacqueline M GarrickLucio G Costa
Sep 10, 2013·Neurotoxicology·Lucio G CostaClement E Furlong
Nov 17, 2011·Critical Reviews in Toxicology·Robyn L PrueittLorenz R Rhomberg
Jun 22, 2016·Annals of Global Health·Judit MarsillachClement E Furlong
May 17, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Charles TimchalkTorka S Poet
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Jun 25, 2009·Current Opinion in Lipidology·Handrean SoranPaul Durrington
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Jun 5, 2003·Pharmacogenetics·Toby B ColeClement E Furlong
Jan 27, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Edward C MeekJanice E Chambers
Feb 24, 2006·Pharmacogenetics and Genomics·Clement E FurlongBrenda Eskenazi

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