Paraoxonase protects against chlorpyrifos toxicity in mice

Toxicology Letters
W F LiL G Costa

Abstract

Paraoxonase can hydrolyze paraoxon (PO), chlorpyrifos-oxon (CPO) and other organophosphates. Previous studies have indicated that the levels of serum paraoxonase can influence the toxicity of PO and CPO. In the present study we have investigated whether exogenous paraoxonase administered to mice would offer protection toward the acute toxicity of a phosphorothioate, chlorpyrifos (CPS). Paraoxonase was purified from rabbit serum and injected i.v., or i.v. plus i.p., in mice. Inhibition of acetylcholinesterase (AChE) in brain, diaphragm, plasma and red blood cells was measured as an index of CPS (100 mg/kg) toxicity. Administration of paraoxonase 30 min before CPS increased plasma enzyme activity toward CPO by 35-fold, and protected against its toxicity; protection was still present at 24 h, when enzyme activity was still 20-fold over basal. When paraoxonase was given 30 min after CPS, a significant protection against CPS toxicity was still observed, while after 3 h the protective effect was decreased. To mimic conditions of severe acute poisoning, a higher dose of CPS (150 mg/kg) was also administered. Administration of paraoxonase 30 min after this exposure abolished cholinergic signs and significantly protected against AChE in...Continue Reading

References

Oct 1, 1976·Journal of Medical Genetics·J R PlayferD A Evans
Mar 1, 1992·Human & Experimental Toxicology·E MutchF M Williams
Mar 15, 1990·Toxicology and Applied Pharmacology·L G CostaC E Furlong
Oct 22, 1991·Biochemistry·C E FurlongJ W Crabb
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·B P DoctorY Ashani
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M I MacknessC H Walker
Aug 1, 1987·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·A D WolfeD Jones
Oct 1, 1993·Journal of Toxicology and Environmental Health·W F LiC E Furlong
Jan 1, 1993·Nature Genetics·R HumbertC E Furlong
Mar 1, 1956·Canadian Journal of Biochemistry and Physiology·A R MAIN
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE

❮ Previous
Next ❯

Citations

Aug 18, 2006·International Archives of Occupational and Environmental Health·Chul-Ho LeeTamie Nakajima
Apr 15, 2004·Toxicology and Applied Pharmacology·Subramanya KaranthCarey Pope
Mar 7, 2003·Toxicology and Applied Pharmacology·Franca M BurattiEmanuela Testai
May 9, 2001·Environment International·L VittozziE Testai
Sep 7, 2001·Toxicology·M Jokanović
Aug 14, 1998·General Pharmacology·B MacknessM I Mackness
Jul 1, 2002·Environmental Toxicology and Pharmacology·Franca M BurattiEmanuela Testai
Jan 11, 2011·Nature Chemical Biology·Rinkoo D GuptaDan S Tawfik
Aug 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Richard C StevensClement E Furlong
May 1, 1997·Journal of Toxicology and Environmental Health·K L YuknavageC E Furlong
Feb 26, 2010·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Gary GinsbergBabasaheb Sonawane
Dec 6, 2005·Journal of Toxicology and Environmental Health. Part a·Dae Ok KimTae Cheon Jeong
Jan 23, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Shelli SchomakerJiri Aubrecht
Nov 30, 2004·Clinical and Experimental Pharmacology & Physiology·T D SutherlandJ G Oakeshott
Jun 29, 2010·Emergency Medicine Journal : EMJ·Na-Na WangMin Zhao
Aug 21, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Simon CroninOrla Hardiman
Dec 25, 2009·Circulation. Cardiovascular Genetics·Rebecca J RichterClement E Furlong
Nov 20, 2009·BMC Clinical Pharmacology·Leonid GaidukovEtgar Levy-Nissenbaum
Jul 27, 1999·Chemico-biological Interactions·L G CostaC E Furlong
Nov 12, 2013·Aging Clinical and Experimental Research·Dileep Kumar, Syed Ibrahim Rizvi
Nov 12, 2014·TheScientificWorldJournal·Priyanka BajajAbhay H Pande
Mar 21, 2003·Journal of Toxicology. Clinical Toxicology·Lucio G CostaClement E Furlong
Feb 3, 2016·Environmental Science and Pollution Research International·Pauline JacquetEric Chabrière
Aug 26, 2011·Toxicology and Applied Pharmacology·Vasilis P AndroutsopoulosAristidis M Tsatsakis
Mar 9, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Manojkumar ValiyaveettilMadhusoodana P Nambiar
Dec 17, 2008·Toxicology and Applied Pharmacology·Rebecca J RichterClement E Furlong
Jun 26, 2008·Toxicology Letters·Ayman Samir Farid, Yoichiro Horii
Feb 28, 2014·Applied Biochemistry and Biotechnology·Priyanka Bajaj, Abhay H Pande
Jun 12, 2014·Clinical and Experimental Pharmacology & Physiology·Zhen-Kun HanMin Zhao
Jan 18, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lucio G CostaClement E Furlong
Jun 23, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H JacobsenO Meyer
May 29, 2007·Chemico-biological Interactions·Jintana SirivarasaiThanyachai Sura
May 4, 2001·American Journal of Human Genetics·V H BrophyC E Furlong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.