Parapharyngeal extension of nasopharyngeal carcinoma: still a significant factor in era of modern radiotherapy?

International Journal of Radiation Oncology, Biology, Physics
Wai T NgCheuk W Choi

Abstract

To retrospectively analyze the prognostic value of parapharyngeal space (PPS) extension after conformal radiotherapy for nasopharyngeal carcinoma. Between 1998 and 2005, 700 patients were treated with conformal radiotherapy at 2 Gy/fraction daily to a total of 70 Gy. All patients underwent staging with magnetic resonance imaging. The incidence of PPS was determined, and the extent of involvement was further subclassified regarding the presence or absence of carotid space (CS) involvement. The prognostic parameters, including age, gender, stage, chemotherapy, additional boosting, and extent of PPS involvement, were analyzed by univariate and multivariate analyses. The median duration of follow-up was 51 months, and the 5-year overall survival rate for the whole group was 73%. The overall incidence of PPS extension was high (74%), and 29% had additional extension to the CS. Multivariate analysis showed age, gender, chemotherapy, T stage, and N stage to be significant prognostic factors, but not PPS involvement with or without CS extension. In the subgroup of patients with Stage T2 disease (n = 242), the presence of PPS involvement alone or PPS plus CS extension had no statistically significant effect in terms of local control (p ...Continue Reading

References

Apr 1, 1991·International Journal of Radiation Oncology, Biology, Physics·S A LeibelZ Y Fuks
Sep 1, 1996·International Journal of Radiation Oncology, Biology, Physics·P TeoP J Johnson
Feb 13, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R M ChauW Y Lee
Aug 3, 2001·International Journal of Radiation Oncology, Biology, Physics·J MaH Q Min
May 10, 2003·International Journal of Radiation Oncology, Biology, Physics·Joseph S K AuW H Lau
Sep 16, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·John WaldronBrian O'Sullivan
Jan 26, 2005·International Journal of Radiation Oncology, Biology, Physics·Skye Hongiun ChengAndrew T Huang
Sep 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne W M LeeUNKNOWN Hong Kong Nasopharyngeal Cancer Study Group

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Citations

Dec 24, 2011·AJR. American Journal of Roentgenology·Ahmed Abdel Khalek Abdel Razek, Ann King
Jul 11, 2012·Chinese Journal of Cancer·Xin-Bin Pan, Xiao-Dong Zhu
Aug 4, 2009·International Journal of Radiation Oncology, Biology, Physics·Frank C S WongStewart Y Tung
Oct 17, 2008·International Journal of Radiation Oncology, Biology, Physics·S H ChanS K Chow
Mar 27, 2012·TheScientificWorldJournal·Jia-Xin LiFei Han
Sep 1, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ling-Long TangJun Ma
Nov 5, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ling-Long TangJun Ma
Oct 22, 2013·International Journal of Pediatric Otorhinolaryngology·Lobna El FikyOssama Hamid

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