Paraphenylene diamine exacerbates platelet aggregation and thrombus formation in response to a low dose of collagen

The Journal of Toxicological Sciences
Younes ZaidAbdellah Bagri

Abstract

Paraphenylene daimine (PPD) is an aromatic amine that is widely used in several industrial products; however, its toxicity has been reported in several cases of cardiac arrests. As platelets play a key role in cardiovascular diseases, we aimed to determine the impact of PPD in vitro and in vivo on platelet function. Our findings demonstrated that platelet activation and aggregation were strongly enhanced by PPD. Treatment with PPD primed human platelets that became more reactive in response to low doses of collagen. Furthermore, PPD exacerbated thrombus formation in rats in comparison with those untreated. Our results suggest that PPD is an important platelet primer predisposing platelets to promote thrombus formation in response to vascular injury. This should prompt the authorities to consider controlling the marketing of this product.

References

Jan 1, 1977·Drug and Chemical Toxicology·C M BurnettB M Lanman
Jan 1, 1992·Annals of Tropical Paediatrics·M Sir HashimG I Sulieman
Jan 1, 1990·Dermatologica·M PicardoB Santucci
Apr 1, 1989·The American Journal of Medicine·M H MustafaL E Pierce
Feb 1, 1987·Contact Dermatitis·B SantucciM Picardo
Nov 1, 1985·Postgraduate Medical Journal·J E Hopkins, A Manoharan
Mar 1, 1994·Human & Experimental Toxicology·W AshrafL J Farrow
Jan 1, 1993·Journal of Toxicology. Clinical Toxicology·M LifshitsS Sofer
Feb 14, 1998·Journal of the American College of Cardiology·M I FurmanA D Michelson
Jul 20, 2002·Journal of Cardiovascular Pharmacology·Alexandre CaronYahye Merhi
Aug 16, 2002·Molecular Pharmacology·Fatih OzdenerJames L Daniel
Oct 22, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·William E Dressler, Terence Appelqvist
Oct 13, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Frédérique Hueber-BeckerHermann M Bolt
Aug 19, 2007·Journal of Postgraduate Medicine·R RamK V Dakshinamurty
Aug 20, 2009·Annals of Tropical Paediatrics·M B AbdelraheemA E Nazik
Apr 19, 2011·Clinics in Dermatology·John P McFaddenJonathan L White
Oct 25, 2013·Cancer Medicine·Niamh M CookeDermot Kenny

❮ Previous
Next ❯

Citations

May 11, 2021·Seminars in Thrombosis and Hemostasis·Youness LimamiYounes Zaid
Nov 9, 2021·Seminars in Thrombosis and Hemostasis·Youness LimamiYounes Zaid

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Journal of the Indian Medical Association
M K DagaN Raizada
The Journal of Pharmacology and Experimental Therapeutics
J E DAVIS
Radiology Management
T V Cryan
© 2022 Meta ULC. All rights reserved