Paraquat induced acute kidney injury and lung fibrosis: a case report from Bangladesh

BMC Research Notes
Ishrat Tahsin IshaFazle Rabbi Chowdhury

Abstract

Since Bangladesh government issued a ban on the use of highly toxic WHO Class I pesticides, annual consumption of herbicides like Paraquat have been sharply increasing in the markets. Paraquat poisoning is an emerging public health threat and its high mortality rate is responsible for a significant number of deaths. Diagnostic limitations and unavailable sample at presentation have resulted in under-reporting and lack of awareness among the treating physicians, making Paraquat poisoning one of the most neglected toxicological emergencies. Herein, we present a case of Paraquat induced multi-organ failure and emphasis on pitfalls in the management. An 18-years-old healthy male was admitted in Sylhet M.A.G Osmani Medical College Hospital with history of attempted suicide by Paraquat ingestion. On admission, he had high serum creatinine but otherwise asymptomatic. He was discharged on day 10 when his renal functions returned to normal. But On day 15, he started having respiratory symptoms-unresponsive to any of the local treatments he received, and by day 30, he developed overt lung fibrosis. We present sequential blood picture, radiographs and CT scans demonstrating Paraquat induced kidney and lung injury over the course of 30 day...Continue Reading

References

Jan 1, 1990·Human & Experimental Toxicology·P HouzéJ M Scherrmann
Apr 1, 1995·Radiology·S H LeeS Y Hong
May 28, 2011·British Journal of Clinical Pharmacology·Indika B Gawarammana, Nicholas A Buckley
Apr 5, 2014·British Journal of Clinical Pharmacology·Klintean WunnapukFlora T Musuamba
Nov 20, 2015·International Journal of Epidemiology·Eun Shil ChaWon Jin Lee
Oct 13, 2017·International Journal of Epidemiology·Fazle Rabbi ChowdhuryMichael Eddleston

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Citations

Dec 30, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Timothy AndersonDeborah A Cory-Slechta
Feb 3, 2021·Critical Reviews in Toxicology·Rajasekaran Subbiah, Rajnarayan R Tiwari

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BETA
lavage

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