PMID: 698141Aug 1, 1978Paper

Paraquat lung injury in rabbits

British Journal of Industrial Medicine
J J SeidenfeldH B Richerson

Abstract

An aerosol model for the study of paraquat (PQ) toxicity was developed using a 134 litre chamber and an ultrasonic nebuliser. Three groups of New Zealand white rabbits weighing 2-3 kg were studied. Group I (n = 6) was exposed to 10 g PQ/100 ml double-distilled water (DDW), Group II (n = 24) was exposed to 200 mg PQ/100 Ml DDW and a control group (n = 6) was exposed to 100 ml DDW. In a second experiment ten animals (Group III) were exposed to 10 mg PQ/100 ML DDW over a three-month period together with a control group (n = 5). Group I animals died with extensive haemorrhagic pneumonitis 38 hours after the last challenge. Most animals in Group II surviving more than three exposures had a significant reduction (P less than 0.001) in arterial oxygen tension (PaO2) and an increase (P less than 0.001) in the alveolar-arterial O2 gradient. Specific compliance decreased (P less than 0.005) and functional residual capacity and breathing frequency increased (P less than 0.05). Tissue PQ values showed even pulmonary distribution, with evidence of PQ accumulation after repeated inhalation. The lungs showed focal interstitial fibrosis, interstitial thickening, proliferation of macrophages in the alveoli, epithelioid changes in the interstiti...Continue Reading

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Citations

Apr 1, 1987·Archives of Toxicology·H Burleigh-Flayer, Y Alarie
Sep 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M SalmonaM Luisetti
Feb 1, 1981·British Journal of Industrial Medicine·I WyattL L Smith
Mar 1, 1985·British Journal of Industrial Medicine·J J SeidenfeldJ M Toyoshima
Feb 1, 1985·The American Journal of the Medical Sciences·J J Seidenfeld
Feb 1, 1979·Chest·H B RichersonP Swanson
Oct 1, 1980·Toxicology and Applied Pharmacology·W J Waddell, C Marlowe
Dec 29, 2007·Critical Reviews in Toxicology·R J Dinis-OliveiraF Carvalho

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