[Paraquat poisoning. Case report and overview].

Medizinische Klinik, Intensivmedizin und Notfallmedizin
T SpangenbergK H Kuck

Abstract

Paraquat poisoning in Germany is rare. Because plasma levels do not necessarily match the ingested amount of paraquat, repeated measurement of plasma levels is imperative. There is a large potential in the prehospital phase to improve prognosis: further resorption must be terminated by rigorous charcoal administration and early tracheal intubation if necessary. Because paraquat can be resorbed by dermal contact, steps to ensure sufficient protection of emergency medical personnel must be taken.As soon as further resorption has been prevented sufficiently, forced diuresis, renal replacement therapy, and hemoperfusion can be of help, but still remain controversial. To reduce pulmonary fibrosis, inspiratory oxygen concentrations must be adjusted to the minimal amount needed to ensure satisfactory tissue oxygenation. Data supporting the advantageous use of cyclophosphamide combined with methylprednisolone for the treatment of pulmonary fibrosis were recently published. Since the toxic mechanism implies a mismatch of oxidants and anti-oxidants, co-administration of ascorbic acid and N-acetylcysteine are simple treatments with few side effects.

References

Feb 1, 1979·Archives of Internal Medicine·N D VaziriS M Rosen
Mar 1, 1976·Forensic Science·D J Carson, E D Carson
Oct 20, 1975·Archives of Toxicology·J M DouzeR H Drost
May 1, 1990·Journal of Applied Physiology·T ShibamotoJ C Parker
Jan 1, 1987·Human Toxicology·A T ProudfootD R Jarvie
Jan 1, 1985·Journal of Toxicology. Clinical Toxicology·F L Van de VyverM E De Broe
Nov 22, 1995·Biochimica Et Biophysica Acta·S H Wright, T M Wunz
May 1, 1994·The Journal of Toxicological Sciences·H Y YuY Z Shen
Jan 1, 1994·Journal of Toxicology. Clinical Toxicology·C KöppelN Schnoy
Oct 1, 1993·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·I Vadnay
Oct 6, 1997·Transplantation·B WalderJ A Romand
Jan 11, 2000·QJM : Monthly Journal of the Association of Physicians·A L JonesR Flanagan
Dec 12, 2001·Toxicology Letters·Sae Yong HongSung Keun Chang
Jan 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ja-Ryong KooJung-Woo Noh
Apr 28, 2005·Archives of Toxicology·Mahmoud Ghazi-KhansariMarzyieh Honarjoo
May 15, 2007·Renal Failure·Andreas SoloukidesValsamakis Hadjiconstantinou
Nov 7, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Su-Ji KimSae-Yong Hong
Nov 11, 2009·Current Opinion in Anaesthesiology·James H Abernathy, Scott T Reeves
Nov 3, 2010·International Immunopharmacology·Qiaoming ZhiLitao Yang
May 28, 2011·British Journal of Clinical Pharmacology·Indika B Gawarammana, Nicholas A Buckley

❮ Previous
Next ❯

Citations

Jul 8, 2021·Environmental Science and Pollution Research International·Yasser El-Nahhal, Ibrahim El-Nahhal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.