Parasagittal organization of the rat cerebellar cortex: direct correlation between antigenic Purkinje cell bands revealed by mabQ113 and the organization of the olivocerebellar projection

The Journal of Comparative Neurology
C GravelR Hawkes

Abstract

The Purkinje cells of the cerebellar cortex and the cortical afferent and efferent projections are organized into parallel parasagittal zones. The parasagittal organization is clearly revealed by immunocytochemistry with a monoclonal antibody, mabQ113. The mabQ113 antigen is confined to a subset of Purkinje cells that are clustered together to form an elaborate, highly reproducible pattern of bands and patches, interspersed with similar mabQ113- regions. The mabQ113+ territories have been classified into seven parasagittal bands (P1+-P7+) in each hemicerebellum. The degree of correspondence between the compartments revealed by the anterograde labeling of the olivocerebellar projection and by mabQ113 immunocytochemistry has been explored in the adult rat. Horseradish peroxide-wheat germ agglutinin conjugate was injected as an anterograde tracer into the inferior olivary complex. When the injection site did not encompass all the olive, an incomplete, patchy labeling of the molecular layer was seen in the cerebellar cortex. Labeled zones of the molecular layer were interrupted by unlabeled regions to give a pattern of parasagittal cortical bands. The positions of these bands were compared with the distribution of the mabQ113+ anti...Continue Reading

References

Jul 15, 1977·The Journal of Comparative Neurology·E MaraniA Boekee
Aug 1, 1977·The Journal of Comparative Neurology·D G GwynB A Flumerfelt
Mar 26, 1986·Brain Research·D T Hess, J Voogd
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·V M IngramB B Owens
Apr 1, 1974·The Journal of Comparative Neurology·D M ArmstrongR F Schild
May 1, 1974·Journal of Neurophysiology·R LlinasC Sotelo
Sep 1, 1970·The Journal of Comparative Neurology·J C VanGilder, J L O'Leary
Sep 26, 1983·Brain Research·N C Campbell, D M Armstrong
Nov 20, 1983·The Journal of Comparative Neurology·L M EisenmanG J Blatt
Jan 1, 1984·Brain, Behavior and Evolution·L M Eisenman
Feb 18, 1982·Nature·G NilaverT L O'Donohue
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·V Chan-PalayT L O'Donohue
Jan 1, 1982·Analytical Biochemistry·R HawkesJ Gordon
Aug 20, 1982·The Journal of Comparative Neurology·B D BeyerlR L Sidman
Dec 1, 1955·A.M.A. Archives of Neurology and Psychiatry·W W CHAMBERS, J M SPRAGUE

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Citations

Jan 1, 1995·Journal of Molecular Neuroscience : MN·R Hawkes, K Herrup
Apr 18, 2008·The Cerebellum·Seung-Hyuk ChungRichard Hawkes
Sep 15, 2010·The Cerebellum·Hassan Marzban, Richard Hawkes
Oct 14, 2010·The Cerebellum·Jakob JankowskiStephan Baader
Feb 28, 1994·Brain Research·Y FuhrmanN Delhaye-Bouchaud
Nov 28, 1989·European Journal of Pharmacology·R L Albin, S Gilman
Jul 1, 1989·Brain Research. Developmental Brain Research·J J Walker, J S King
Jun 21, 1991·Brain Research. Developmental Brain Research·L M EisenmanJ Voogd
Nov 19, 1991·Brain Research. Developmental Brain Research·M D Willcutts, M Morrison-Bogorad
Jan 1, 1991·Progress in Neurobiology·R Hawkes, C Gravel
Jun 6, 2003·Brain Research·Roy V SillitoeRichard Hawkes
Apr 30, 2002·Brain Research. Developmental Brain Research·Sana D KaramMark Bothwell
Feb 19, 2002·The European Journal of Neuroscience·Akos KulikRyuichi Shigemoto
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N LeclercM Yamamoto
Aug 1, 1993·Neuropathology and Applied Neurobiology·C GerloffB Volk
Apr 25, 2012·Development, Growth & Differentiation·Mitsuhiro Hashimoto, Masahiko Hibi
Jan 1, 1996·The European Journal of Neuroscience·F TouriB M Riederer
May 1, 1996·The European Journal of Neuroscience·M ZagrebelskyP Strata
May 18, 2007·Annual Review of Cell and Developmental Biology·Roy V Sillitoe, Alexandra L Joyner
Jan 1, 1997·Annual Review of Neuroscience·K Herrup, B Kuemerle

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