ParaSight-F test for the detection of treatment failure in multidrug resistant Plasmodium falciparum malaria

Transactions of the Royal Society of Tropical Medicine and Hygiene
J KarbwangW Rooney

Abstract

The ParaSight-F test for the detection of Plasmodium falciparum was evaluated for its accuracy and usefulness in predicting treatment outcome in 75 patients (70 males, 5 females) with acute uncomplicated malaria who attended a malaria clinic in Mae Sot, Tak province, on the Thai-Myanmar border. All patients were admitted to the clinic for 28 d to exclude reinfection. The test was performed using blood samples collected into ethylenediaminetetraacetic acid from the patients on admission, and on days 1, 2, 7, and 14. The presence of microscopically detectable parasitaemia was used as the reference for sensitivity and specificity of the test. The reappearance of parasites on day 28 was used to determine the accuracy of predicting the outcome of artemether treatment on day 14. The sensitivity of the ParaSight-F test on admission, and on days 1, 2, 7, and 14, was 98.7%, 96.7%, 100%, 100% and 100%, respectively, with corresponding specificities of 50%, 24.2%, 47.1% and 72.9%. The sensitivity for predicting recrudescence by using the test on day 14 was 100%, with 97.7% specificity, and the sensitivity of predicting a sensitive response on day 14 was 97.7%, with 100% specificity. The test seems to permit more precise detection of treat...Continue Reading

References

Jul 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·Z PremjiC J Shiff
Nov 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·C J ShiffJ N Minjas

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Citations

May 18, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·M MayxayN J White
Jul 1, 1997·Transactions of the Royal Society of Tropical Medicine and Hygiene·H M KodisingheK N Mendis
Aug 6, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·A BartoloniF Paradisi
Dec 23, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·J Van den EndeL Lynen
Jul 11, 1998·Infectious Disease Clinics of North America·A J Magill
Sep 30, 2000·Clinical and Laboratory Haematology·A H Moody, P L Chiodini
Jan 19, 2008·Clinical Microbiology Reviews·Clinton K MurrayR Scott Miller
Jan 10, 2002·Clinical Microbiology Reviews·Anthony Moody
Nov 28, 2002·Journal of Clinical Microbiology·Jamshaid IqbalParsotam R Hira
Jun 24, 2009·Interdisciplinary Perspectives on Infectious Diseases·Clinton K Murray, Jason W Bennett
Dec 19, 2014·The Cochrane Database of Systematic Reviews·Katharine AbbaYemisi Takwoingi
Jul 8, 2011·The Cochrane Database of Systematic Reviews·Katharine AbbaPaul Garner
Jun 10, 2018·Malaria Journal·Ursula DalrympleEwan Cameron

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