PMID: 6980921Sep 1, 1982Paper

Parasite- (antigen) specific stimulation of B and T cells in African trypanosomiasis

The Journal of Immunology : Official Journal of the American Association of Immunologists
G CampbellS M Phillips

Abstract

C57BL/6J mice were immunized with irradiated Trypanosoma rhodesiense organisms. Splenic lymphocytes were subsequently obtained from immunized animals and were tested for blast transformation in vitro after exposure to soluble trypanosome antigens. Immune T lymphocytes were found to be the cells responsible for antigen-mediated blastogenesis to trypanosome antigens. In addition, trypanosome antigen preparations in higher concentrations stimulated B lymphocytes obtained from normal nonimmunized animals.

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African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.