Parasite density and serum cytokine levels in Plasmodium vivax malaria in Turkey

Parasite Immunology
Fadile Yildiz ZeyrekZ Simsek

Abstract

We aimed to investigate the relationship between quantitative Plasmodium vivax parasitaemia and serum cytokine levels in a highly endemic region of Turkey, where such a relation has not been investigated before. Active screening was done in a total of 1316 people residing in 33 villages of Sanliurfa province, Turkey. The study population consisted of 79 consecutive patients with P. vivax malaria, and a control group included 89 healthy subjects. Thick blood smears were examined for malaria parasite and parasite count. Serum samples were analysed for IL-1beta, IL-2, IL-4, IL-6, IL-8, IL-10 and IL-12 by the ELISA method. Compared to controls, levels of pro-inflammatory cytokines, i.e. IL-1beta, IL-6 and IL-12, were significantly higher in patients with parasitaemia. There was a significant positive correlation between serum IL-10 and IL-12 levels and the parasite burden (r = 0.264, P = 0.024 and r = 0.264, P = 0.024, respectively). Serum IL-8 levels showed a significant negative correlation with parasite burden (r =-0.356, P = 0.002). There was a positive correlation between IL-8 levels and age, while the opposite was observed for IL-12. High fever was correlated with IL-6 and IL-10 levels. Compared to controls, patients with a p...Continue Reading

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·N D KarunaweeraK N Mendis
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·M SedegahS L Hoffman
Jul 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A D Urquhart
Feb 1, 1993·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S PartanenJ Lähdevirta
Feb 1, 1994·Clinical and Experimental Immunology·F PeyronJ Banchereau
Jan 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·J S FriedlandG E Griffin
Dec 10, 1997·The American Journal of Tropical Medicine and Hygiene·R UdomsangpetchS Looareesuwan
Mar 21, 1998·The American Journal of Tropical Medicine and Hygiene·N D KarunaweeraK N Mendis
Aug 11, 1998·The Journal of Infectious Diseases·M HoN J White
Oct 9, 1999·The Journal of Infectious Diseases·H BrownT Taylor
Dec 10, 1999·The American Journal of Tropical Medicine and Hygiene·D PrybylskiG T Strickland
Jan 19, 2000·Parasitology Today·I Taverne
Jun 27, 2001·The American Journal of Tropical Medicine and Hygiene·K MendisR Carter
Jul 24, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·J JasonW R Jarvis
May 17, 2002·International Journal of STD & AIDS·L DixonD J Clutterbuck
Aug 2, 2002·The Lancet Infectious Diseases·Lucia Malaguarnera, Salvatore Musumeci
Dec 7, 2002·The Lancet Infectious Diseases·Donato TorreRoberto Martegani
Jan 10, 2003·The American Journal of Tropical Medicine and Hygiene·Anita D Praba-EggeMark A James
Mar 20, 2003·Immunology Letters·Pio ContiTheoharis C Theoharides
Mar 26, 2003·Parasite Immunology·Lucia MalaguarneraSalvatore Musumeci
Apr 12, 2003·Trends in Parasitology·Nadira D KarunaweeraRichard Carter
Jul 2, 2003·Annals of Tropical Medicine and Parasitology·A D Praba-EggeM A James
Jul 20, 2004·Annals of Tropical Medicine and Parasitology·M A KurcerS Topluoglu
Aug 25, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·Joon-Sup YeomJae-Won Park

❮ Previous
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Citations

Jul 16, 2009·Médecine sciences : M/S·Stéphane Picot, Anne-Lise Bienvenu
Jun 12, 2012·Malaria Journal·Chuchard PunsawadParnpen Viriyavejakul
Aug 30, 2008·PLoS Computational Biology·Philip G McQueen, F Ellis McKenzie
Dec 2, 2010·The American Journal of Tropical Medicine and Hygiene·Fadile Yildiz ZeyrekKazuyuki Tanabe
Jul 8, 2011·The American Journal of Tropical Medicine and Hygiene·Justin M CurleyRobert A Gasser
Mar 8, 2016·Acta Tropica·Edson Fredulin SchererEduardo Luzía França
Oct 1, 2008·European Journal of Immunology·Kulachart JangpatarapongsaRachanee Udomsangpetch
Jan 15, 2013·Journal of Tropical Medicine·Vitor R R de MendonçaManoel Barral-Netto
May 24, 2014·Pathogens and Global Health·Raquel Müller GonçalvesMarcelo Urbano Ferreira
Jun 1, 2013·PloS One·Helena Cristina C CoelhoMarcus V G Lacerda
Jan 26, 2017·Malaria Journal·Natália Satchiko Hojo-SouzaLilian Lacerda Bueno
Jun 30, 2010·The Korean Journal of Parasitology·Ahmet GencIsmail Soner Koltas
Jul 9, 2009·Annals of Tropical Medicine and Parasitology·C O FaladeO G Ademowo
Mar 16, 2017·Malaria Journal·Larissa W BrasilRajendranath Ramasawmy
Oct 9, 2020·Scientific Reports·Letusa AlbrechtFabio T M Costa

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