Parasite genome initiatives

International Journal for Parasitology
W M DegraveM Aslett

Abstract

During 1993-1994, scientists from developing and developed countries planned and initiated a number of parasite genome projects and several consortiums for the mapping and sequencing of these medium-sized genomes were established, often based on already ongoing scientific collaborations. Financial and other support came from WHO/TDR, Wellcome Trust and other funding agencies. Thus, the genomes of Plasmodium falciparum, Schistosoma mansoni, Trypanosoma cruzi, Leishmania major, Trypanosoma brucei, Brugia malayi and other pathogenic nematodes are now under study. From an initial phase of network formation, mapping efforts and resource building (EST, GSS, phage, cosmid, BAC and YAC library constructions), sequencing was initiated in gene discovery projects but soon also on a small chromosome, and now on a fully fledged genome scale. Proteomics, functional analysis, genetic manipulation and microarray analysis are ongoing to different degrees in the respective genome initiatives, and as the funding for the whole genome sequencing becomes secured, most of the participating laboratories, apart from larger sequencing centres, become oriented to post-genomics. Bioinformatics networks are being expanded, including in developing countries...Continue Reading

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Citations

Feb 21, 2002·Current Infectious Disease Reports·Paul B. Keiser, Thomas B. Nutman
Apr 14, 2005·International Journal for Parasitology·E A Worthey, P J Myler
Mar 23, 2005·Trends in Parasitology·David G BironFrédéric Thomas
Apr 12, 2002·International Journal for Parasitology·Paul T MonisChristopher P Saint
Nov 7, 2003·Lancet·Michael P BarrettSanjeev Krishna
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Sep 12, 2003·Molecular and Biochemical Parasitology·Todd A MinningRick L Tarleton
Jan 13, 2004·Computer Methods and Programs in Biomedicine·Daniel Nilsson, Björn Andersson
Oct 2, 2003·Trends in Parasitology·Alberto M R DávilaSara E Melville
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Jul 2, 2005·Expert Opinion on Emerging Drugs·Piero OlliaroFelipe Guhl
Feb 17, 2005·Experimental Parasitology·Daniel Nilsson, Björn Andersson
Jun 26, 2004·International Journal for Parasitology·Adriana Parodi-TaliceCarlos Robello
Apr 15, 2014·Trends in Ecology & Evolution·Javier del CampoIñaki Ruiz-Trillo
Dec 4, 2003·Cellular Microbiology·Jane M Carlton
Apr 20, 2002·Current Opinion in Infectious Diseases·T B Nutman
Nov 29, 2002·Eukaryotic Cell·Linda SperlingJean Cohen

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