Parasite infectivity and immunity to Plasmodium falciparum gametocytes in Gambian children

Parasite Immunology
Chris DrakeleyG A Targett

Abstract

Immunity to the sexual stages of Plasmodium falciparum can be induced during natural infections. Characterization of this immunity may facilitate the design of a transmission-blocking vaccine (TBV). This study aimed to assess the prevalence and serological correlates of functional transmission-blocking immunity in Gambian children (aged 1-4 years old) who were P. falciparum gametocyte carriers. Serological assays showed 100% response to fixed, whole parasites but only 42% to live gametes. Responses to the antigens Pfs230 and Pfs48/45 were 54.1% and 37.3%, respectively, in an IgG1 ELISA. 14/55 sera were capable of reducing the infectivity of laboratory isolate NF54 in a standard membrane-feeding assay (SMFA). This activity was strongly correlated with IgG1 responses to Pfs48/45 (r = 0.49, P < 0.001) and to a serological reaction with epitopes of the same molecule (r = 0.38, P = 0.003). A weaker correlation was observed with IgG1 to Pfs230 (r = 0.29, P = 0.03). In direct membrane feeding assays (DMFA) with autologous isolates, sera from 4/29 children showed transmission-blocking activity. There was no correlation with serological assays and the DMFA or between the SMFA and DMFA. This may be caused by variation in sexual stage ant...Continue Reading

References

Jan 1, 1982·Transactions of the Royal Society of Tropical Medicine and Hygiene·T PonnuduraiA H Lensen
Sep 1, 1994·The American Journal of Tropical Medicine and Hygiene·P F BillingsleyR E Sinden
Jan 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·A LensenR Sauerwein
Feb 1, 1997·International Journal for Parasitology·D C Kaslow
Apr 17, 1999·Tropical Medicine & International Health : TM & IH·C J DrakeleyG A Targett

❮ Previous
Next ❯

Citations

Nov 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sophie H AdjalleyDavid A Fidock
Apr 14, 2010·PLoS Pathogens·Melissa R van DijkChris J Janse
Jan 26, 2008·Emerging Infectious Diseases·Didier MénardLéon Paul Rabarijaona
Oct 30, 2010·Emerging Infectious Diseases·Stanislas RebaudetChristophe Rogier
Jul 18, 2012·The American Journal of Tropical Medicine and Hygiene·Kailash P Patra, Joseph M Vinetz
Jan 9, 2016·Parasitology·Will J R StoneSanna R Rijpma
Oct 27, 2010·International Journal for Parasitology·Teun BousemaChris J Drakeley
Jan 20, 2015·Nature Communications·Thomas S ChurcherAnna Cohuet
Oct 14, 2010·Malaria Journal·André Lin OuédraogoRobert Sauerwein
Dec 6, 2008·Malaria Journal·Kasia StepniewskaNicholas J White
Apr 21, 2005·PLoS Medicine·Colin J SutherlandGeoffrey A T Targett
Oct 18, 2016·The Indian Journal of Medical Research·Neha ChaturvediNeeru Singh
Sep 4, 2014·Memórias do Instituto Oswaldo Cruz·Ryan C SmithMarcelo Jacobs-Lorena
Feb 10, 2018·Nature Communications·Will J R StoneMatthijs M Jore
Apr 26, 2018·The American Journal of Tropical Medicine and Hygiene·Bismarck DinkoKirk W Deitsch
Dec 17, 2019·Immunological Reviews·Roos M de JongTeun Bousema
Feb 26, 2019·Frontiers in Immunology·Jonas A Kengne-OuafoBismarck Dinko
Jul 19, 2017·The American Journal of Tropical Medicine and Hygiene·Mahamadoun Hamady AssadouOgobara K Doumbo
Apr 10, 2019·Infection and Immunity·Festus K AcquahLinda E Amoah
Dec 3, 2016·International Journal for Parasitology·Silvia A Arredondo, Stefan H I Kappe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.