Parasites and individual major histocompatibility complex diversity--an optimal choice?

Microbes and Infection
K Mathias WegnerThorsten B H Reusch

Abstract

Overdominant selection or heterozygote advantage can partly explain the extraordinary polymorphism found at classical major histocompatibility complex (MHC) loci. However, several studies employing only single infectious agents often failed to detect it. Here, we review recent studies suggesting that due to the dominant nature of MHC-mediated resistance, a heterozygote advantage is most likely to be detected in multiple pathogen challenges.

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M A NowakJ M Austyn
Jul 1, 1993·The Journal of Experimental Medicine·R M ChiczJ L Strominger
Jan 1, 1996·Immunogenetics·S H van ErpR J Stet
Mar 22, 1996·Proceedings. Biological Sciences·T von SchantzK Persson
Jan 1, 1997·Critical Reviews in Immunology·V ApaniusW K Potts
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·S PatersonJ M Pemberton
Jun 3, 1998·Proceedings. Biological Sciences·T RülickeC Wedekind
Mar 12, 1999·Science·M CarringtonS J O'Brien
Jul 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·V Detours, A S Perelson
Dec 29, 2000·Immunogenetics·H WesterdahlT von Schantz
Aug 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·Dustin J PennWayne K Potts
Oct 25, 2002·Proceedings. Biological Sciences·Jakob LohmTorbjörn von Schantz
Jan 10, 2003·Nucleic Acids Research·James RobinsonSteven G E Marsh
Mar 26, 2003·Infection and Immunity·Erin E McClellandWayne K Potts
Sep 6, 2003·Science·K Mathias WegnerManfred Milinski
Nov 25, 2003·European Journal of Immunology·José A M BorghansRob J De Boer
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Bryan D Neff
Apr 3, 2004·Proceedings. Biological Sciences·Joachim KurtzManfred Milinski

❮ Previous
Next ❯

Citations

Jun 17, 2006·Proceedings. Biological Sciences·Joachim KurtzManfred Milinski
Mar 28, 2008·Proceedings. Biological Sciences·Sofia Consuegra, Carlos Garcia de Leaniz
Jun 12, 2009·Proceedings. Biological Sciences·Jukka KekäläinenJouni Taskinen
May 6, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mélanie DionneLouis Bernatchez
Feb 18, 2012·BMC Evolutionary Biology·Helmut SchaschlWalter Arnold
Jul 28, 2010·Immunogenetics·Claus OppeltDietrich von Holst
Sep 5, 2007·Evolution; International Journal of Organic Evolution·Adin Ross-GillespieLukas F Keller
Jul 20, 2005·Trends in Immunology·Andreas ZieglerBarbara Uchanska-Ziegler
Feb 19, 2015·Ecology and Evolution·Virginie NepouxArnaud Le Rouzic
Jun 20, 2015·Journal of Immunology Research·Martin Těšický, Michal Vinkler
May 7, 2020·Ecology Letters·Nina Hafer-Hahmann, Christoph Vorburger
Feb 14, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Edward E Schmidt, Christopher J Davies
Mar 9, 2021·Frontiers in Cellular and Infection Microbiology·Mukesh SamantPrashant Khare
Mar 6, 2021·Evolution; International Journal of Organic Evolution·Emily A O'Connor, Helena Westerdahl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.