Parasitic diarrheal disease: drug development and targets

Frontiers in Microbiology
Amir AzamKamal Ahmad

Abstract

Diarrhea is the manifestation of gastrointestinal infection and is one of the major causes of mortality and morbidity specifically among the children of less than 5 years age worldwide. Moreover, in recent years there has been a rise in the number of reports of intestinal infections continuously in the industrialized world. These are largely related to waterborne and food borne outbreaks. These occur by the pathogenesis of both prokaryotic and eukaryotic organisms like bacteria and parasites. The parasitic intestinal infection has remained mostly unexplored and under assessed in terms of therapeutic development. The lack of new drugs and the risk of resistance have led us to carry out this review on drug development for parasitic diarrheal diseases. The major focus has been depicted on commercially available drugs, currently synthesized active heterocyclic compounds and unique drug targets, that are vital for the existence and growth of the parasites and can be further exploited for the search of therapeutically active anti-parasitic agents.

References

Jan 1, 1978·Transactions of the Royal Society of Tropical Medicine and Hygiene·L S DiamondC C Cunnick
Aug 28, 1975·The New England Journal of Medicine·K W PykeE W Gelfand
Jul 1, 1991·Clinical Microbiology Reviews·W L Current, L S Garcia
Aug 1, 1990·International Journal for Parasitology·P J SchofieldW J O'Sullivan
Aug 1, 1989·The Journal of Infectious Diseases·X Sáez-Llorens
Sep 15, 1988·Annals of Internal Medicine·L M WeissM Wittner
Sep 1, 1988·The Journal of Infectious Diseases·K L MuseyA Fourrier
Oct 1, 1986·Journal of Clinical Microbiology·D J SheehanJ C McKitrick
Jul 1, 1981·Pathology·T Butler, W G De Boer
Jun 19, 1980·Biochimica Et Biophysica Acta·P A Friedman, E G Platzer
Jun 1, 1980·Acta Pathologica Et Microbiologica Scandinavica. Section B, Microbiology·D J FergusonJ C Siim
Jul 10, 1993·Lancet·G MadicoC R Sterling
Jan 1, 1994·Molecular and Biochemical Parasitology·W W ZhangJ Samuelson
Oct 1, 1996·European Journal of Biochemistry·D M BrownP Upcroft
Oct 1, 1996·Diagnostic Microbiology and Infectious Disease·A Ebrahimzadeh, E J Bottone
May 14, 1998·The Journal of Antimicrobial Chemotherapy·D E UipD Bem David
Jun 19, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J A Upcroft, P Upcroft
Apr 30, 1999·International Journal for Parasitology·J Kulda
Nov 24, 1999·The American Journal of Gastroenterology·U Z OkA A Kilimcioğlu
Sep 13, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D C Hooper
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R L GuerrantInfectious Diseases Society of America
Feb 24, 2001·Bioorganic & Medicinal Chemistry Letters·Gabriel Navarrete-VázquezR Castillo
Jun 20, 2001·The Journal of Eukaryotic Microbiology·C J BacchiM Wittner
Jun 8, 2002·Mutation Research·Andrés BendeskyPatricia Ostrosky-Wegman
Jun 21, 2002·The New England Journal of Medicine·Jean-Michel MolinaAgence Nationale de Recherches sur le SIDA 090 Study Group
Jul 20, 2002·Bioorganic & Medicinal Chemistry Letters·Juan ValdezRafael Castillo
Jul 20, 2002·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Jan R Mead
Sep 25, 2002·Journal of Molecular Biology·Adela Rodríguez-RomeroD Alejandro Fernández-Velasco
Jan 15, 2003·Current Infectious Disease Reports·Richard Goodgame
Apr 18, 2003·The New England Journal of Medicine·Rashidul HaqueWilliam A Petri
Oct 7, 2003·Bioorganic & Medicinal Chemistry·Gabriel Navarrete-VázquezRafael Castillo
Oct 29, 2003·Trends in Parasitology·William A Petri
Mar 27, 2004·Science·Mitchell S AbrahamsenVivek Kapur
Aug 18, 2004·International Journal for Parasitology·Julio C CarreroJuan P Laclette
Sep 10, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul R HunterJohn Goodacre
Dec 1, 1992·Parasitology Today·James A ReynoldsonR J Horton
Dec 17, 2004·The Pediatric Infectious Disease Journal·Adriana H TremouletIdis Faingezicht
Jan 25, 2005·Trends in Parasitology·Edoardo Pozio, Maria Angeles Gomez Morales
Feb 25, 2005·Antimicrobial Agents and Chemotherapy·Cynthia Ordaz-PichardoMireya de la Garza
Feb 25, 2005·Nature·Brendan LoftusNeil Hall
May 26, 2005·Parasitology Research·Davood Dorostkar MoghaddamM Azami
Jun 1, 2005·Water Research·David E JohnCharles P Gerba
Jul 12, 2005·Folia Parasitologica·Elizabeth S DidierPeter J Didier
May 26, 2006·Antimicrobial Agents and Chemotherapy·Peter J DidierElizabeth S Didier
Jun 20, 2006·Bioorganic & Medicinal Chemistry·Alice Maria Rolim BernardinoMarcos A Vannier-Santos
Aug 2, 2006·Gastroenterology Clinics of North America·David B Huang, A Clinton White
Aug 19, 2006·Antimicrobial Agents and Chemotherapy·Rajendra UpadhyaLouis M Weiss
Aug 31, 2006·Current Opinion in Infectious Diseases·Elizabeth S Didier, Louis M Weiss
Feb 13, 2007·Travel Medicine and Infectious Disease·Muhammad R Sohail, Philip R Fischer
Apr 18, 2007·Antimicrobial Agents and Chemotherapy·Joachim MüllerAndrew Hemphill
Aug 19, 2007·Expert Opinion on Pharmacotherapy·Angel A Escobedo, Sergio Cimerman
May 20, 2008·Bioorganic & Medicinal Chemistry Letters·Héctor Torres-GómezGabriel Navarrete-Vázquez
Aug 5, 2008·European Journal of Medicinal Chemistry·Prince Firdoos IqbalAmir Azam
Sep 26, 2008·Parasite : Journal De La Société Française De Parasitologie·G Gargala
Feb 12, 2009·European Journal of Medicinal Chemistry·Emanuel Hernández-NúñezGabriel Navarrete-Vázquez
Nov 17, 2009·International Journal of Antimicrobial Agents·Dan SatoTomoyoshi Nozaki
Jun 15, 2010·Parasitology Research·Fadime Eroglu, Ismail Soner Koltas
Jul 8, 2010·Archives of Pharmacal Research·Zygmunt KazimierczukStanislaw J Chrapusta
Dec 22, 2010·Digestive Diseases and Sciences·Elizabeth W HwangChristine A Cartwright
Feb 24, 2011·Parasitology Research·Zofi GraczykThaddeus K Graczyk
Mar 15, 2011·Bioorganic & Medicinal Chemistry Letters·Gabriel Navarrete-VázquezEmanuel Hernández-Núñez
Apr 5, 2011·The American Journal of Tropical Medicine and Hygiene·Stephen BeckerEric R Houpt
Sep 21, 2011·PLoS Neglected Tropical Diseases·Koji WatanabeShinichi Oka
Jan 13, 2012·European Journal of Medicinal Chemistry·Mohmmad Younus WaniFareeda Athar
Sep 18, 2012·The Pediatric Infectious Disease Journal·Mahmoud AgholiMohammad Hossein Motazedian
Oct 12, 2012·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Jaap J van HellemondPerry J J van Genderen
Jan 9, 2013·Clinical Microbiology Reviews·Maha BouzidKevin M Tyler
Jan 22, 2013·Diagnostic Microbiology and Infectious Disease·Haendel G N O BusattiMaria A Gomes
May 31, 2013·Journal of the Royal Army Medical Corps·Michael J World
Jun 22, 2013·Bioorganic & Medicinal Chemistry·Blanca Estela Duque-MontañoOscar Torres-Angeles
Feb 18, 2014·Bioorganic & Medicinal Chemistry·Carlos Nava-ZuazoGabriel Navarrete-Vázquez
Feb 22, 2014·The Journal of Biological Chemistry·Andrey GalkinOsnat Herzberg
May 14, 2014·Antimicrobial Agents and Chemotherapy·Anjan DebnathJames H McKerrow
Jul 25, 2014·International Journal for Parasitology. Drugs and Drug Resistance·Katherine T AndrewsTina S Skinner-Adams
Aug 26, 2014·ACS Medicinal Chemistry Letters·Kavitha MandapatiLizbeth Hedstrom
May 30, 2015·European Journal of Medicinal Chemistry·Saadia Leeza ZaidiAmir Azam
Jun 3, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yanis Toledano-MagañaBlanca M Cabrera-Vivas
Jul 16, 2015·Bioorganic & Medicinal Chemistry Letters·Mohammad Fawad AnsariAmir Azam
Apr 22, 2016·International Journal for Parasitology. Drugs and Drug Resistance·Joachim MüllerNorbert Müller

Methods Mentioned

BETA
acetylation

Related Concepts

Antineoplastic Agents
Heterocyclic Compounds
Intestinal Diseases, Parasitic
Parasites
Intestinal Fluke Infection (Disorder)
Drug Interactions
Pathogenesis
Pharmacologic Substance
Diarrheal Disorder
Resistance Process

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