Parasitic infections during pregnancy need not affect infant antibody responses to early vaccination against Streptococcus pneumoniae, diphtheria, or Haemophilus influenzae type B

PLoS Neglected Tropical Diseases
Noah D McKittrickA Desiree Labeaud

Abstract

Globally, vaccine-preventable diseases remain a significant cause of early childhood mortality despite concerted efforts to improve vaccine coverage. One reason for impaired protection may be the influence of prenatal exposure to parasitic antigens on the developing immune system. Prior research had shown a decrease in infant vaccine response after in utero parasite exposure among a maternal cohort without aggressive preventive treatment. This study investigated the effect of maternal parasitic infections on infant vaccination in a more recent setting of active anti-parasitic therapy. From 2013-2015, 576 Kenyan women were tested in pregnancy for malaria, soil-transmitted helminths, filaria, and S. haematobium, with both acute and prophylactic antiparasitic therapies given. After birth, 567 infants received 10-valent S. pneumoniae conjugate vaccine and pentavalent vaccine for hepatitis B, pertussis, tetanus, H. influenzae type B (Hib) and C. diphtheriae toxoid (Dp-t) at 6, 10, and 14 weeks. Infant serum samples from birth, 10 and 14 weeks, and every six months until age three years, were analyzed using a multiplex bead assay to quantify IgG for Hib, Dp-t, and the ten pneumococcal serotypes. Antenatal parasitic prevalence was hig...Continue Reading

References

Jun 24, 1978·Lancet·W A Williamson, B M Greenwood
Jan 22, 1972·Lancet·B M GreenwoodA Palit
Jul 1, 1970·The Journal of Pediatrics·L M DubowitzC Goldberg
Sep 26, 2006·Lancet·Tessa WardlawElizabeth Mason
Dec 15, 2006·The New England Journal of Medicine·Mark A Pallansch, Hardeep S Sandhu
Jun 26, 2007·Veterinary Parasitology·Joseph F UrbanWilliam C Gause
Jun 12, 2008·Bulletin of the World Health Organization·Shabir A MadhiThomas Cherian
Jan 14, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J NdibazzaA M Elliott
May 14, 2010·Clinical and Vaccine Immunology : CVI·Stanley A Plotkin
Aug 20, 2011·Clinical and Vaccine Immunology : CVI·D GoldblattG M Carlone
Mar 18, 2017·Pediatrics·Monica Nayakwadi SingerA Desirée LaBeaud
Apr 14, 2017·Clinical and Vaccine Immunology : CVI·Noah D McKittrickA Desiree LaBeaud
Mar 1, 2018·The American Journal of Tropical Medicine and Hygiene·Claire J HeathA Desiree LaBeaud

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

R Core Team
R

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.