Parasiticidal activity of human alpha-defensin-5 against Toxoplasma gondii.

In Vitro Cellular & Developmental Biology. Animal
Tetsuya TanakaKozo Fujisaki

Abstract

Human defensins play a fundamental role in the initiation of innate immune responses to some microbial pathogens. In this paper, we show that human alpha-defensin-5 displays a parasiticidal role against Toxoplasma gondii, the causative agent of toxoplasmosis. Exposure of the tachyzoite form of T. gondii to defensin induced aggregation and significantly reduced parasite viability in a concentration-dependent peptide. Pre-incubation of tachyzoites with human alpha-defensin-5 followed by exposure to a mouse embryonal cell line (NIH/3T3) significantly reduced T. gondii infection in these cells. Thus, human alpha-defensin-5 is an innate immune molecule that causes severe toxocity to T. gondii and plays an important role in reducing cellular infection. This is the first report showing that human alpha-defensin-5 causes aggregation, leading to Toxoplasma destruction.

References

Jan 1, 1995·Annual Review of Immunology·H G Boman
Sep 1, 1994·Protein Science : a Publication of the Protein Society·W C WimleyS H White
Dec 1, 1994·Infection and Immunity·S B AleyF D Gillin
Dec 24, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T IhiS Matsukura
Jul 10, 1998·Molecular and Biochemical Parasitology·B StriepenD S Roos
Feb 27, 1999·Current Opinion in Immunology·R I Lehrer, T Ganz
May 21, 1999·Science·J A HoffmannR A Ezekowitz
May 16, 2002·Infection and Immunity·Gillian MorrisonJulia Dorin
May 16, 2002·Infection and Immunity·Christian MoserJames M Wilson
Jun 26, 2003·The Journal of Infectious Diseases·Bradford S McGwireDavid M Engman
Sep 2, 2003·Nature Reviews. Immunology·Tomas Ganz
Mar 17, 2004·Peptides·Jon-Paul S Powers, Robert E W Hancock
Feb 11, 2005·Nature Reviews. Microbiology·Kim A Brogden
Oct 18, 2005·Peptides·Haiqin ChenPeilin Cen
Dec 13, 2005·Current Opinion in Immunology·Kelly L Brown, Robert E W Hancock
Dec 13, 2006·Nature Biotechnology·Robert E W Hancock, Hans-Georg Sahl
Aug 29, 2007·Antimicrobial Agents and Chemotherapy·Ling C HuangAlison M McDermott
Feb 17, 2009·Trends in Immunology·Yuping Lai, Richard L Gallo

❮ Previous
Next ❯

Citations

Aug 24, 2010·Cell and Tissue Research·Linda Hazlett, Minhao Wu
Nov 22, 2011·Tropical Animal Health and Production·Remil Linggatong GalayKozo Fujisaki
Oct 23, 2013·PLoS Neglected Tropical Diseases·Sara DabirianSima Rafati
Mar 7, 2014·Pharmaceuticals·Jorge A Masso-Silva, Gill Diamond
Jan 13, 2015·Research in Veterinary Science·Shouzhen XuDavid Bravo
Sep 10, 2014·Parasite Immunology·C L Wilhelm, F Yarovinsky
May 8, 2018·Frontiers in Microbiology·Laura GiovatiLaura H Kramer
Apr 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alina SecrieruMaria L S Cristiano
Apr 25, 2018·Infection and Immunity·Eduardo R CoboKris Chadee
Dec 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Nicolas GuyotCéline Landon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.