Parasitized Natural Killer cells do not facilitate the spread of Toxoplasma gondii to the brain

Parasite Immunology
L Petit-JentreauJanine L Coombes

Abstract

Toxoplasma gondii is a protozoan parasite capable of invading immune cells and co-opting their migratory pathways to disseminate through the host. Natural Killer (NK) cells can be directly invaded by the parasite and this invasion alters NK cell migration, producing a hypermotile phenotype. However, the consequences of this hypermotile phenotype for the dissemination of T. gondii to the brain remain unknown. To address this, C57BL6/J mice were infected with freshly egressed tachyzoites (type IIPrugniaud strain) or with parasitized NK cells. Under both conditions, parasite loads in the brain were comparable, indicating that parasitized NK cells were not able to facilitate spread of T. gondii to the brain. Consistent with this, we found no evidence for the recruitment of endogenous NK cells to the brain at early time points post-infection, nor any changes in the expression of α4β1 integrin, involved in recruitment of NK cells to the brain. We therefore found no evidence for a role for hypermotile NK cells in delivery of parasites to the brain during acute infection with T. gondii.

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Citations

Feb 13, 2020·Mucosal Immunology·Goo-Young SeoMitchell Kronenberg
Mar 16, 2019·Frontiers in Immunology·Daria L IvanovaJason P Gigley

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Methods Mentioned

BETA
flow cytometry
Fluorescence
PCR

Software Mentioned

FlowJo
Treestar
GraphPad
Prism

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