PMID: 2122461Nov 1, 1990Paper

Parasitoid virus-like particles destroy Drosophila cellular immunity

Proceedings of the National Academy of Sciences of the United States of America
R M Rizki, T M Rizki

Abstract

Parasitoid wasps must avoid the destructive effects of the host's cellular defense system in order to exploit the host hemocoel as a suitable environment for their survival. To protect their eggs from encapsulation by Drosophila melanogaster blood cells, Leptopilina heterotoma females inject a factor that selectively destroys lamellocytes, the type of Drosophila blood cell involved in recognition and encapsulation of large foreign objects. Other types of host blood cells, including the phagocytic plasmatocytes, remain functional. This report demonstrates that the destructive factor for lamellocytes is a virus-like particle (VLP) stored in the reservoir of an accessory gland associated with the female wasp reproductive system. We show that VLPs enter Drosophila blood cells in vitro. VLPs are found free in the cytoplasm of lamellocytes but are confined to phagocytic vesicles of plasmatocytes. As lamellocytes are susceptible to the VLP infection and plasmatocytes are not, we conclude that the mode of VLP entry and its disposition in the cytoplasm determine the fate of the infected host blood cell.

References

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Citations

Jan 17, 2012·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Nicole Stange, Bernhard Ronacher
Mar 1, 1992·Developmental and Comparative Immunology·T M Rizki, R M Rizki
Jun 1, 1996·Insect Biochemistry and Molecular Biology·A YamanakaH Watanabe
May 29, 2003·Journal of Insect Physiology·James B Whitfield, Sassan Asgari
Dec 19, 2002·Trends in Parasitology·Christophe Boëte, Jacob C Koella
Mar 8, 2003·Parasitology·A R KraaijeveldH C J Godfray
Feb 26, 2000·Heredity·M D Fellowes, H C Godfray
Aug 30, 2011·Molecular Biology and Evolution·Erin S Keebaugh, Todd A Schlenke
Aug 13, 2004·Proceedings. Biological Sciences·Christophe BoëteJacob C Koella
Aug 14, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Elisabeth A HerniouJean-Michel Drezen
Oct 30, 2001·Evolution; International Journal of Organic Evolution·A R KraaijeveldH C Godfray
Apr 15, 1994·Annals of the New York Academy of Sciences·T M Rizki, R M Rizki
Jan 28, 1998·Annual Review of Entomology·J B Whitfield
Jan 5, 2007·Annual Review of Immunology·Bruno Lemaitre, Jules Hoffmann
Jan 2, 2008·PLoS Pathogens·Dominique ColinetMarylène Poirié
Sep 9, 2010·Annual Review of Entomology·Sassan Asgari, David B Rivers
May 22, 2013·Proceedings of the National Academy of Sciences of the United States of America·Nathan T MortimerTodd A Schlenke
Oct 30, 2012·Journal of Insect Physiology·Dominique ColinetMarylène Poirié
Oct 18, 2012·Journal of Insect Physiology·Sébastien J M Moreau
Mar 14, 2009·Comptes rendus biologies·Marylène PoiriéAurore Dubuffet
Feb 3, 2015·Current Opinion in Insect Science·Mary E HeavnerShubha Govind
Feb 1, 2008·Insect Science·Shubha Govind
Dec 20, 2007·Arthropod Structure & Development·Hege Vårdal

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