Parasitological and immunological aspects of Trypanosoma cruzi infection in nude rats

Zeitschrift Für Parasitenkunde
A M RodriguezA Capron

Abstract

The role of the thymus on immunity of rats against Trypanosoma cruzi infection was investigated in vivo. The athymic (nu/nu) rats were shown to be significantly more susceptible to the acute phase of the infection than the control nu/+ rats, as measured by increased parasitemia and mortality. Specific anti-T. cruzi antibodies, complement, IgM and IgG2a serum levels were determined. The results would indicate the essential role of antibodies in immunity to acute Chagas' disease through T-dependent immune response.

References

Apr 1, 1979·Infection and Immunity·F Kierszenbaum, M M Pienkowski
Dec 1, 1977·Parasitology·I A Abrahamsohn, W D Silva
Oct 1, 1973·Experimental Parasitology·E L Roberson, W L Hanson
May 1, 1980·Infection and Immunity·A P Dalmasso, J A Jarvinen
Feb 1, 1981·Infection and Immunity·A M RodriguezA Capron

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