PMID: 9536501Apr 16, 1998Paper

Parasympathetic neuropathy associated with left ventricular diastolic dysfunction in patients with insulin-dependent diabetes mellitus

Scandinavian Cardiovascular Journal : SCJ
R B WillenheimerG Sundkvist

Abstract

Patients with insulin-dependent diabetes mellitus (IDDM) may develop autonomic neuropathy (AN) and cardiac complications. The association between AN and cardiac dysfunction was assessed in 34 IDDM patients (age 40 years, diabetes duration 21 years, 15 women) by echocardiography/Doppler and autonomic nerve function tests. The expiration/inspiration ratio (E/I) was used to assess parasympathetic damage, and the acceleration and brake indices for assessment of sympathetic impairment. AN was present in 21 patients. Patients with abnormal E/I (n = 11) had lower E/A ratios than patients without AN; early to atrial peak filling ratio (E/Amax) was median 1.1 (inter-quartile range 0.2) vs 1.4 (0.7), p = 0.022; early to atrial integral filling ratio (E/Aintegral) was 1.7 (0.3) vs 2.3 (1.2), p = 0.006. Patients with AN and normal E/I (sympathetic neuropathy, n = 10) and patients without AN had similar E/A ratios. E/Aintegral was also lower in patients with abnormal E/I compared with patients with AN and normal E/I; 1.7 (0.3) vs 2.2 (0.7), p = 0.008. Systolic function and cardiac dimensions were generally unaffected and similar in the three groups. In conclusion, diastolic dysfunction and parasympathetic neuropathy are related in IDDM pati...Continue Reading

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Citations

Jul 27, 2001·Diabetes Technology & Therapeutics·M J Stevens
Nov 9, 2010·Vascular Health and Risk Management·Christina VoulgariNicholas Tentolouris
Aug 23, 2000·Medicina clínica·A Fernández-FúnezA Hernández
Jan 2, 2007·Autonomic Neuroscience : Basic & Clinical·Miguel Debono, Elaine Cachia
May 25, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·M TaskiranJ Hilsted
Mar 21, 2015·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Valeria MilazzoSimona Maule
Dec 27, 2011·Journal of Cardiac Failure·S Michael GharacholouPatricia A Pellikka
Aug 21, 2002·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·Radu NegoesAlin Achim
Jul 20, 2002·Journal of Diabetes and Its Complications·M A KowalewskiJ Peczynska

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