Paratesticular alveolar rhabdomyosarcomas do not harbor typical translocations: a distinct entity with favorable prognosis?

Virchows Archiv : an International Journal of Pathology
Tobias M DantonelloCooperative Weichteilsarkom Studiengruppe (CWS)

Abstract

The alveolar subtype of rhabdomyosarcoma (RMA) is a strong risk factor. Cases of RMA located in paratesticular sites have however been reported to have similar outcomes to those of embryonal rhabdomyosarcoma (RME). We wanted to re-evaluate the impact of subtype in paratesticular rhabdomyosarcoma (PT-RMS). Patients from a population-based cohort diagnosed with paratesticular RMA in 1990-2013 were analyzed. All tumor samples were re-reviewed using conventional morphology, immunohistochemistry, and molecular testing. Seven patients were eligible. Four tumors showed focal areas morphologically compatible with RMA (mixed RMA/RME). One case was undifferentiated, with a solid round-cell morphology which had to be reclassified as poorly differentiated RME. Two cases had a "microalveolar" morphology which is today regarded as sclerosing RME. No tumor showed the characteristic gene fusion of RMA. Five children had localized disease, one bone metastases, and another lymph-node involvement. All primaries were grossly resected. One locoregional relapse occurred. At a median follow-up of 7 years, all patients were alive disease-free. PT-RMS can show a focal alveolar histology combined with typical features of RME. In current morphological cl...Continue Reading

References

Mar 1, 1992·The American Journal of Surgical Pathology·A O CavazzanaG Salviati
Nov 1, 1991·Genes, Chromosomes & Cancer·J A BiegelB S Emanuel
Nov 30, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E KoscielniakJ Treuner
Jun 2, 2000·Virchows Archiv : an International Journal of Pathology·T Mentzel, D Katenkamp
Jun 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W M CristS S Donaldson
Jan 12, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A FerrariM Carli
Mar 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard J StewartUNKNOWN International Society of Pediatric Oncology
May 7, 2005·Wiener klinische Wochenschrift·Ditha ModritzJörn Treuner
Apr 12, 2006·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jun NishioJulia A Bridge
Dec 14, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Thomas WeihkopfPeter Kaatsch
Jan 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tobias M DantonelloEwa Koscielniak
Jan 30, 2009·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Jitsupa TreetipsatitShanop Shuangshoti
Feb 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tobias M DantonelloEwa Koscielniak
Mar 31, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leonard H Wexler, Marc Ladanyi
Mar 31, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel WilliamsonOlivier Delattre
Aug 11, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James R AndersonTimothy J Triche
Mar 29, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edoardo MissiagliaJanet Shipley
May 9, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Abby R RosenbergDouglas S Hawkins
Jun 6, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William H Meyer
Oct 4, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sabine StegmaierEwa Koscielniak
Oct 12, 2013·Advances in Anatomic Pathology·David M Parham, Frederic G Barr
Sep 30, 2014·Pediatric Blood & Cancer·Tobias M DantonelloUNKNOWN Cooperative Weichteilsarkom Studiengruppe [CWS]
Nov 5, 2014·International Journal of Cancer. Journal International Du Cancer·Friederike ErdmannJoachim Schüz
Dec 10, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A FerrariD Orbach

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