Parathormone Levels in a Middle-Eastern Healthy Population Using 2nd and 3rd Generation PTH Assays

International Journal of Endocrinology
Marie-Hélène Gannagé-YaredGhassan Sleilaty

Abstract

The purpose of the current study is to determine PTH reference values in vitamin-D-replete Lebanese adults using 2nd and 3rd generation PTH assays and to look at the factors that affect PTH variations. Fasting PTH was measured using 2nd and 3rd generation Diasorin PTH assays in 339 vitamin-D-replete healthy subjects aged 18 to 63 years (230 men and 109 women) who have normal calcium levels and an eGFR ≥60 ml/mn. 25-OH vitamin D (25(OH)D) was measured using the Diasorin assay. For the 2nd PTH generation, median (IQR) levels were 48.9 (34.9-66.0) pg/ml, and its 2.5th-97.5th percentile values were 19.7-110.5 pg/ml for 25(OH)D values between 20 and 30 ng/ml, and 19.7-110.7 pg/ml for 25(OH)D values ≥30 ng/ml. For the 3rd PTH generation, the median (IQR) values were 23.9 (17.7-30.5) pg/ml, and its 2.5th-97.5th percentile values were, respectively, 9.2 and 50.2 pg/ml for 25(OH)D values between 20 and 30 ng/ml, and 8.4 and 45.4 pg/ml for 25(OH)D values ≥30 ng/ml. The median (IQR) serum 25(OH)D levels were 27.5 (23.8-32.7) ng/ml. 2nd and 3rd generation PTH values are strongly correlated (r = 0.96, p < 0.0001), but poorly concordant (Lin's concordance coefficient 0.365, 95% CI: 0.328-0.401) with observations beyond the 95% Bland-Altman l...Continue Reading

References

Sep 8, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M H Gannagé-YaredG Halaby
Aug 7, 2004·European Journal of Endocrinology·Elena KamychevaRolf Jorde
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
May 11, 2010·Bone·Asma ArabiGhada El-Hajj Fuleihan
Jun 4, 2010·The Journal of Clinical Endocrinology and Metabolism·Etienne CavalierAlbert Beckers
Nov 3, 2010·Clinical Endocrinology·Lars RejnmarkLeif Mosekilde
Nov 20, 2010·American Journal of Clinical Pathology·Sonia L La'ulu, William L Roberts
Dec 2, 2010·The Journal of Clinical Endocrinology and Metabolism·A Catharine RossSue A Shapses
Sep 24, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Etienne CavalierJean-Claude Souberbielle
Jun 9, 2012·Annales d'endocrinologie·Jean-Claude SouberbielleCatherine Cormier
Aug 31, 2012·The Journal of Clinical Endocrinology and Metabolism·A ValcourSudhaker D Rao
Dec 12, 2012·Clinical Biochemistry·Manfred HeckingChristian Bieglmayer
Apr 30, 2013·American Heart Journal·Adriana J van BallegooijenIngeborg A Brouwer
Jun 19, 2013·Metabolism: Clinical and Experimental·Marie-Hélène Gannagé-YaredDania Chelala
Feb 18, 2014·The Journal of Clinical Endocrinology and Metabolism·Mathilde TouvierJean-Claude Souberbielle
Aug 28, 2014·The Journal of Clinical Endocrinology and Metabolism·Richard EastellRajesh V Thakker
Jun 3, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Etienne CavalierJean-Claude Souberbielle
Jan 7, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M LiW Xia
Feb 3, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Bo YangYukang Cao
Oct 4, 2016·Journal of Endocrinological Investigation·J-C SouberbielleE Cavalier
Nov 5, 2016·Archives of Endocrinology and Metabolism·Teresa Cristina P BonanséaJosé Gilberto Henriques Vieira
Jun 30, 2018·Bone Reports·Marlene ChakhtouraGhada El-Hajj Fuleihan
Sep 6, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Anne Marie DupuyJean Paul Cristol

❮ Previous
Next ❯

Methods Mentioned

BETA
sandwich assay
blood collection

Software Mentioned

SPSS
SUVIMAX

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition
K NakamuraM Yamamoto
Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
John F AloiaJames K Yeh
Clinica Chimica Acta; International Journal of Clinical Chemistry
M M L DeckersA C Heijboer
© 2021 Meta ULC. All rights reserved