Parathyroid autotransplantation

Archives of Surgery
M HerreraL A Fitzpatrick

Abstract

Although rare following initial cervical exploration, reoperative parathyroid surgery may cause permanent hypoparathyroidism in 15% to 30% of patients. Immediate fresh or delayed cryopreserved parathyroid autotransplantation is the principal surgical option to resolve this complication. Between 1980 and 1990, 18 and 12 patients underwent immediate and cryopreserved autotransplantation, respectively. With a mean follow-up of nearly 5 years, 61% of the immediate and 42% of the cryopreserved tissue showed evidence of function. However, only 10 (55%) and two (17%) of the respective patients had completely discontinued treatment with calcium supplementation. Graft-dependent hypercalcemia can occur with either technique. We conclude that until cryopreserved tissue can be transplanted with more reliable success and if the excised abnormal parathyroid likely represents the only remaining gland, we would advise immediate autotransplantation. In the reoperative setting, unless a residual normal parathyroid gland is confirmed, a portion of the excised parathyroid tissue should be cryopreserved for possible autotransplantation in case hypoparathyroidism develops subsequently.

Citations

Jan 5, 2011·International Journal of Endocrinology·Marlon A Guerrero
Jan 22, 2005·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·K SchlosserM Rothmund
Mar 19, 2013·Annals of Surgical Oncology·Kevin ShepetHerbert Chen
Sep 4, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Hae Sang ParkHan Su Kim
May 28, 2014·Arquivos brasileiros de endocrinologia e metabologia·Ana K N LeiteFábio L de M Montenegro
Sep 14, 2011·World Journal of Surgery·Carlos Eduardo Santa Ritta BarreiraFábio Luiz de Menezes Montenegro
Mar 14, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Edwina C MooreSajal Gupta
Dec 18, 2002·ANZ Journal of Surgery·Chung-Yau Lo
Mar 19, 2014·Head & Neck·Imdat YüceErcihan Güney
Jul 3, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Brendan C StackGregory W Randolph
Jan 30, 2008·World Journal of Surgery·Marlon A GuerreroNancy D Perrier
Mar 29, 2019·World Journal of Surgery·Guillermo Ponce de León-BallesterosMiguel F Herrera
Jun 14, 2003·Otolaryngologic Clinics of North America·Brian D AffleckJoseph Brennan

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