Parathyroid carcinoma

Current Opinion in Otolaryngology & Head and Neck Surgery
Jay GoswamyRicard Simo

Abstract

This article highlights recent advances in our understanding of the incidence, epidemiology, clinical presentation, evaluation, diagnosis, treatment, and prognosis of parathyroid carcinoma. The prevalence of parathyroid carcinoma is approximately 0.005% of all cancers. Therefore, parathyroid carcinoma is one of the rarest malignancies known. Patients with parathyroid carcinoma present with clinical symptoms of hypercalcaemia as these cancers are usually hormonally functional. It is not uncommon that patients present with complications of profound hypercalcaemia because of an elevated parathyroid hormone. Parathyroid carcinoma is difficult to diagnose preoperatively unless patients present with metastatic disease. Serum calcium often exceeds 14 mg/dl and serum parathyroid hormone is significantly elevated commonly between three and 10 times of the upper limit. Fine needle aspiration is not recommended because of the risk of parathyromatosis. Treatment includes surgery as a primary form of therapy and this usually follows with postoperative radiotherapy, although its use remains controversial. Patients with parathyroid carcinoma should undergo adequate surgical excision with an attempt of preserving vital structures such as the r...Continue Reading

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Citations

Oct 30, 2016·Journal of Surgical Oncology·Ioannis ChristakisNancy D Perrier
Feb 6, 2017·International Journal of Molecular Sciences·Chiara Verdelli, Sabrina Corbetta
Nov 27, 2018·The Journal of Endocrinology·Manuel D GaheteRaul M Luque
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Mar 28, 2020·International Journal of Endocrinology·Francesco QuaglinoElena Castellano
Nov 15, 2018·Case Reports in Surgery·Raoul VerzijlJesse D Pasternak
Jul 31, 2019·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·S WächterE Maurer
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Dec 5, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B SunY Fan
Jan 19, 2021·HNO·T Novosel, J Podzimek

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Methods Mentioned

BETA
surgical resection
dissection

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