Parathyroid glands: combination of sestamibi-(99m)Tc scintigraphy and ultrasonography for demonstration of hyperplasic parathyroid glands

Revista española de medicina nuclear
E T P KasaiE Boasquevisque

Abstract

To determine the frequency of the types of parathyroid gland hyperplasia and the sensitivity of sestamibi-(99m)Tc (MIBI) scintigraphy and ultrasonography (US) of patients with secondary hyperparathyroidism (SHPT) due to chronic renal failure. We studied 43 patients with SHPT (26 females and 17 males with age range of 27-75 years). Blood tests were performed to determine intact parathyroid hormone (PTH), calcium and phosphorus concentration and parathyroid MIBI scintigraphy and US examinations were done, to evaluate each glandular function and structure. Nineteen of the 43 patients underwent total parathyroidectomy and 69 abnormal glands were removed at operation. The 69 abnormal and 4 normal glands from patients that underwent total thyroidectomy were studied by light microscopy. The results were compared and correlation was calculated to: weight, MIBI uptake and US results. All 43 patients had elevated serum PTH ranged from 400 to 4,075 pg/ml (1,868.0 +/- 975.9 and normal range 10-75 pg/ml). Serum calcium and phosphorus concentration were 10.13 +/- 2.02 mg/dl and 5.28 +/- 2.07 mg/dl respectively. Fifty eight of 69 glands from surgical resection were MIBI positive and 11 were negative, but their cellular composition and present...Continue Reading

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Citations

Dec 5, 2009·The Journal of Laryngology and Otology·A A Awobem, R J A England
Sep 12, 2008·The New England Journal of Medicine·Hari K V S KumarKirtikumar D Modi
Dec 5, 2009·Surgery·Daniel RepplingerRebecca S Sippel
Apr 11, 2017·Revista española de medicina nuclear e imagen molecular·J R Oliver GuillénM C Casamayor Franco
Feb 11, 2012·Endocrine Journal·Afshin MohammadiMohammad Ghasemi-rad
Nov 14, 2013·Cardiology Research and Practice·Arturo Orea-TejedaZuilma Vázquez-Ortíz

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