Parathyroid hormone added to established hormone therapy: effects on vertebral fracture and maintenance of bone mass after parathyroid hormone withdrawal

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
F CosmanR Lindsay

Abstract

Our best pharmacologic agents for osteoporosis treatment prevent no more than 40-60% of osteoporotic fractures in patients at highest risk. Thus, there is a need for agents that can further augment bone mass and reduce fracture risk more substantially. To this end, we investigated the utility of parathyroid hormone (PTH) in combination with established hormone-replacement therapy (HRT) in women with osteoporosis. Fifty-two women who had been on HRT for at least 2 years were enrolled in this trial in which 25 were assigned randomly to remain on HRT alone and 27 were assigned to remain on HRT and also receive daily subcutaneous PTH(1-34) 400 U (25 microg) per day for 3 years. Bone mineral density (BMD) measurements at the spine, hip, and total body as well as biochemical determinations of bone turnover and calcium homeostasis were obtained every 6 months. Lateral thoracic and lumbar spine X-rays were obtained at baseline and annually. Subjects also had measurements of bone density and biochemical indices of bone turnover 1 year after discontinuation of PTH, while HRT was continued. In the group receiving HRT alone, bone density and biochemical variables of bone turnover remained stable throughout the 3-year treatment trial and 1-...Continue Reading

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References

Nov 1, 1983·Annals of Internal Medicine·B Frame, G M Marel
Jun 20, 1998·Calcified Tissue International·F Cosman, R Lindsay
Jun 17, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·F CosmanR Lindsay
Oct 3, 1998·JAMA : the Journal of the American Medical Association·J S FinkelsteinR M Neer
Aug 17, 1999·The Journal of Clinical Investigation·R L JilkaS C Manolagas
Nov 7, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T FujitaM Fukunaga
Jan 7, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S E HallR L Prince
Feb 9, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J ReginsterR Eastell
May 10, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N E LaneC D Arnaud
Sep 22, 2000·The Journal of Clinical Endocrinology and Metabolism·E S KurlandJ P Bilezikian
Feb 15, 2001·The New England Journal of Medicine·M R McClungUNKNOWN Hip Intervention Program Study Group
Jun 2, 2001·The New England Journal of Medicine·K L Sauder

❮ Previous
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Citations

Aug 13, 2003·Southern Medical Journal·Ronald C Hamdy
May 6, 2014·BoneKEy Reports·Felicia Cosman
Feb 5, 2002·General and Comparative Endocrinology·Suchinda MalaivijitnondWichai Cherdshewasart
Sep 11, 2014·European Journal of Clinical Pharmacology·Sri Harsha Tella, J Christopher Gallagher
Mar 1, 2007·Women's Health·John P Bilezikian
Mar 12, 2005·Current Rheumatology Reports·Neil Binkley, Diane Krueger
Feb 20, 2003·Current Rheumatology Reports·James F Whitfield
Feb 23, 2002·BMJ : British Medical Journal·Jonathan Reeve
Jul 5, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Ann CranneyUNKNOWN Clinical Guidelines Committee of Osteoporosis Canada
Oct 24, 2009·Arthritis Research & Therapy·Kenneth G Saag, Piet Geusens
Feb 19, 2010·The Journal of Clinical Endocrinology and Metabolism·Joel S FinkelsteinRobert M Neer
Jun 29, 2011·Reviews in Endocrine & Metabolic Disorders·Erik Fink Eriksen
May 15, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Akiko Iida-KleinRobert Lindsay
Jul 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Armen H Tashjian, Bruce A Chabner
Jan 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Robert MarcusBruce Mitlak
Jan 13, 2012·Calcified Tissue International·Peter SchwarzPeter Vestergaard
Jul 16, 2002·Current Opinion in Rheumatology·Mishaela R Rubin, John P Bilezikian
Oct 18, 2006·Reviews in Endocrine & Metabolic Disorders·Monica GirotraJohn P Bilezikian
Jun 4, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Etah S KurlandJohn P Bilezikian
Sep 5, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P VestergaardP Schwarz
Oct 12, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F CosmanR Lindsay
Oct 17, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S AdamiA Sipos
Mar 16, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L ZhangG Yang
Sep 17, 2009·Der Unfallchirurg·B Schmidt-RohlfingH C Pape
Oct 7, 2009·Journal of Bone and Mineral Metabolism·Kathryn M RyderMitchell A Watsky
May 24, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·Michael R McClung
Jul 30, 2009·Wiener medizinische Wochenschrift. Supplement·Hans Peter DimaiUNKNOWN Austrian Society for Bone and Mineral Research (AuSBMR)
Jul 23, 2005·Current Osteoporosis Reports·James F Whitfield
Jul 23, 2005·Current Osteoporosis Reports·Marie-Paul LecartJean-Yves Reginster
Nov 24, 2005·Current Osteoporosis Reports·Neil Binkley, Diane Krueger
Mar 11, 2006·Current Osteoporosis Reports·John P Bilezikian, Mishaela R Rubin
Jun 22, 2010·Current Osteoporosis Reports·Jean-Pierre DevogelaerDaniel H Manicourt
Aug 16, 2001·Trends in Endocrinology and Metabolism : TEM·E Seeman, P D Delmas
Aug 12, 2005·The New England Journal of Medicine·Felicia CosmanRobert Lindsay
Dec 12, 2003·Joint, Bone, Spine : Revue Du Rhumatisme·Françoise Debiais
Oct 12, 2004·Joint, Bone, Spine : Revue Du Rhumatisme·Bernard Cortet
Mar 6, 2015·Climacteric : the Journal of the International Menopause Society·S Palacios, A Mejía
Jun 15, 2011·Current Medical Research and Opinion·E Michael Lewiecki
Feb 24, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R LindsayJ J Stepan
Apr 23, 2005·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Kenneth I ShulmanPaula Rochon

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