Parathyroid hormone enhances early and suppresses late stages of osteogenic and chondrogenic development in a BMP-dependent mesenchymal differentiation system (C3H10T1/2)

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
A HollnagelG Gross

Abstract

The role of parathyroid hormone (PTH) upon osteo-/chondrogenic development was investigated in a bone morphogenetic protein (BMP)-dependent differentiation system involving the recombinant expression of BMPs in mesenchymal progenitor cells (C3H10T1/2). The constitutive expression of the PTH/PTH related protein receptor in this system led to a marked stimulation of chondrogenic and osteogenic development, while the permanent application of the ligand PTH(1-34) resulted in opposite responses by stimulating the early and suppressing the late stages of osteo-/chondrogenic development. These contrasting effects of PTH(1-34) on osteogenic and chondrocytic development seem, therefore, to depend on the cellular state of differentiation. The osteogenic and chondrocytic differentiation potential was substantiated histologically and by genetic analyses of marker genes like c-fos, alkaline phosphatase, osteocalcin, collagen alpha1(I), and collagen alpha1(II). The capacity to regulate osteogenic and chondrogenic development is located in the amino-terminal (1-34) region of the PTH molecule and seems to be mediated by the cyclic adenosine monophosphate signaling cascade. The application of other PTH domains like PTH(28-48) and PTH(53-84) did...Continue Reading

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Citations

Sep 14, 2001·Biochemical and Biophysical Research Communications·T KawaneN Horiuchi
Apr 6, 2006·The Journal of Clinical Investigation·Andrea HoffmannDan Gazit
Feb 15, 2013·Expert Reviews in Molecular Medicine·Shannon H Carroll, Katya Ravid
Sep 1, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P C SchillerG A Howard
Oct 12, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·W JuD Huylebroeck
Oct 9, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nobuhiro KamiyaHideto Watanabe
Jan 26, 2005·Biomechanics and Modeling in Mechanobiology·S H ElderW R McCulley
Sep 29, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·K SugaK Miyata
Jun 20, 2001·Biological & Pharmaceutical Bulletin·Y Nishiya, S Sugimoto
Oct 1, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Daniel J LeeRegis J O'Keefe
Sep 17, 2013·Journal of Tissue Engineering and Regenerative Medicine·Yoshihiro DogakiMasahiro Kurosaka
Feb 3, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Morgane LockerAnne Poliard
Jun 3, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R JemtlandK M Gautvik
Nov 19, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Geertje van der HorstMarcel Karperien
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May 17, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bing YuXu Cao

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