Parathyroid hormone increases bone formation and improves mineral balance in vitamin D-deficient female rats

Endocrinology
A ToromanoffJ L Riond

Abstract

The present study was designed to investigate whether enhanced bone formation due to intermittent PTH administration is dependent on vitamin D metabolites. Forty-eight female Sprague-Dawley rats were randomized into four groups: 1) vitamin D-sufficient, saline-injected (+D Sal); 2) vitamin D-sufficient, human (h) PTH-(1-38)-treated (+D PTH); 3) vitamin D-deficient, saline-injected (-D Sal); and 4) vitamin D-deficient, hPTH-(1-38)-treated (-D PTH) animals. The -D diet contained 2% calcium (Ca), 1.25% phosphorus (P), and 20% lactose to maintain normocalcemia and normophosphatemia despite vitamin D deficiency. The +D diet contained 0.8% Ca, 0.5% P, 20% lactose, and 1000 IU/kg vitamin D. After 45 days of either diet, the rats were injected with 50 microg/kg BW PTH or saline, s.c., daily for 2 weeks. Serum Ca, Mg, P, albumin, and creatinine were similar in all groups. PTH administration decreased endogenous PTH concentrations in the -D PTH compared with those in the - D Sal group. Serum alkaline phosphatase activity, bone mass measurements, dual energy x-ray absortiometric analysis of mineral density, and mechanical testing values in vertebrae and femora of the -D Sal animals did not significantly differ from those in +D Sal animals...Continue Reading

References

Oct 1, 1975·The Journal of Clinical Investigation·J E Russell, L V Avioli
Jan 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J M Hock, I Gera
Apr 1, 1992·Proceedings of the Society for Experimental Biology and Medicine·M R WaltersJ Fox
Mar 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P AmmannJ P Bonjour
Oct 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C C LiuM Ray
Jan 1, 1991·The Journal of Nutrition·L L HardwickD B Lee
Mar 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·U KollenkirchenM R Walters
Jan 1, 1990·Annual Review of Nutrition·T SudaN Takahashi
Jun 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J M HockL G Raisz
Aug 1, 1987·The Journal of Nutrition·F Bronner
Jan 1, 1987·The Journal of Membrane Biology·J L Madara, J R Pappenheimer
Jun 27, 1970·Lancet·D N KaluG V Foster
Oct 1, 1967·Endocrinology·F LifshitzH E Harrison
Jan 1, 1984·Metabolic Bone Disease & Related Research·M Gunness-Hey, J M Hock
Apr 1, 1994·Physiological Reviews·C de Rouffignac, G Quamme
Jan 1, 1996·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P AmmannJ P Bonjour

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Citations

Jun 28, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E E HohmanC M Weaver
Feb 5, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C A FrolikJ M Hock
Mar 29, 2008·Archives of Oral Biology·Mona Aly AbbassyKunimichi Soma
Sep 22, 2016·Basic & Clinical Pharmacology & Toxicology·Raul Hernandes BortolinAdriana Augusto de Rezende
Nov 4, 2000·Expert Opinion on Investigational Drugs·J WhitfieldG Willick
Dec 9, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C M WeaverM Wastney
Feb 27, 2007·Archives of Biochemistry and Biophysics·Hidetake FujinakaTatsuo Suda

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