Parathyroid hormone is predictive of low bone mass in Canadian aboriginal and white women

Bone
Hope A WeilerCharles N Bernstein

Abstract

Canadian Aboriginal women have lower age- and weight-corrected bone mineral density (BMD) and lower vitamin D status than White women. This study was undertaken to describe the differences in biomarkers of bone metabolism and vitamin D in Aboriginal and non-Aboriginal women and to establish which biomarkers were predictive of BMD. In total, 41 rural Aboriginal, 212 urban Aboriginal and 182 urban White women were studied for BMD of the distal radius, calcaneus, lumbar spine, femoral neck, total hip and whole body using dual-energy X-ray absorptiometry. Serum biomarkers measured included calcium, phosphate, alkaline phosphatase (ALP), C-telopeptide of type 1 collagen (CTX), osteocalcin (OC), osteoprotegerin (OPG), parathyroid hormone (PTH) and 25(OH)D. Data were analyzed for differences among the three groups stratified by age (25 to 39, 40 to 59 and 60 to 75 y) using factorial ANOVA. Predictors of BMD including ethnicity, age and body weight were identified using step-wise regression. Unadjusted BMD of all sites declined with age regardless of ethnic grouping. Prediction models for 5 of 6 BMD sites included PTH accounting for age and body weight. Other predictors of BMD included OC for the radius and calcaneus; OPG for spine and...Continue Reading

References

Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M C ChapuyP J Meunier
Nov 11, 1998·Journal of the American Geriatrics Society·H M PerryJ E Morley
Apr 28, 1999·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·R TheilerH A Bischoff
Feb 24, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J E Aubin, E Bonnelye
Feb 24, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A TenenhouseUNKNOWN CaMos Research Group.Canadian Multicentre Osteoporosis Study
Apr 24, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·G Martínez Díaz-GuerraM Díaz-Curiel
Apr 12, 2003·Journal of Cellular Biochemistry·Rachel M LocklinB Lawrence Riggs
Aug 9, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Geeta HampsonIgnac Fogelman
Jan 27, 2004·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Edward S LeibUNKNOWN International Society for Clinical Densitometry
Apr 8, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Julie A PascoGeoffrey C Nicholson
Jun 19, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H P BhattoaA Balogh
Oct 13, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·William D LeslieLeslie L Roos
Mar 19, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Bess Dawson-HughesReinhold Vieth
Apr 2, 2005·Inflammatory Bowel Diseases·Charles N BernsteinWilliam D Leslie
Sep 9, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W D LeslieJ D O'Neil

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Citations

Jul 3, 2013·Environmental Health : a Global Access Science Source·Alexandra-Cristina PaunescuPierre Ayotte
Aug 24, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L S Greene-FinestoneUNKNOWN CaMos Research Group
Oct 2, 2009·Schizophrenia Bulletin·Bruce I TuretskyPaul J Moberg
Apr 15, 2011·Proceedings. Biological Sciences·Darla K ZelenitskyLawrence M Witmer
Feb 5, 2013·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Melissa S Putman, Catherine M Gordon
Aug 18, 2012·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Tom J HazellHope A Weiler

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