Parathyroid Hormone Levels Are Independently Associated with eGFR and Albuminuria: The Dong-gu Study

Journal of Nutritional Science and Vitaminology
Seong-Woo ChoiMin-Ho Shin

Abstract

Increased parathyroid hormone (PTH) was associated with cardiovascular mortality and morbidity in CKD patients. Our aim was to investigate the associations among estimated glomerular filtration rate (eGFR), albumin/creatinine ratio (ACR) and PTH independent of 25-hydroxyvitamin D (25(OH)D). This study included 9,162 individuals who completed the baseline survey of the Dong-gu Study, which was conducted in Korea from 2007 to 2010. The eGFR, ACR, PTH and 25(OH)D were measured in participants who met the detailed inclusion criteria. After being adjusting for covariates (sex, age, waist circumference, smoking, alcohol intake, physical activity, hypertension medications, diabetes medication, total cholesterol, triglyceride, HDL cholesterol) and log-ACR, the PTH value stratified by 25(OH)D level significantly decreased with increasing eGFR levels in each 25(OH)D stratum. Moreover, after adjustment for the same covariates and log-eGFR, the PTH value stratified by 25(OH)D level significantly increased with increasing ACR levels in each 25(OH)D stratum. In conclusion, the PTH values significantly decreased with increasing eGFR levels and increased with increasing ACR levels independently of 25(OH)D in an adult Korean population ≥50 y of...Continue Reading

References

Jan 1, 1991·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·H ReichelE Ritz
Aug 1, 1982·The Journal of Clinical Endocrinology and Metabolism·J C Nainby-LuxmooreT Y Barnes
Aug 31, 2001·Journal of the American College of Cardiology·M G ShlipakUNKNOWN Heart and Estrogen/progestin Replacement Study (HERS) Investigators
Jun 29, 2002·Journal of the American Academy of Nurse Practitioners·Mary Jo Goolsby
Dec 10, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Cynthia S RitterAlex J Brown
Apr 17, 2003·Kidney & Blood Pressure Research·Vlado PerkovicGavin J Becker
Jul 12, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Thomas J WeberL Darryl Quarles
Jul 1, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Yan Chun LiJuan Kong
Oct 16, 2004·Kidney International. Supplement·Gonzalo Calvo, Fernando de Andres-Trelles
Nov 17, 2004·The Journal of Clinical Investigation·William M Deen
Mar 2, 2006·American Journal of Physiology. Endocrinology and Metabolism·Jun SunYan Chun Li
Nov 8, 2007·JAMA : the Journal of the American Medical Association·Josef CoreshAndrew S Levey
Nov 10, 2007·The Journal of Clinical Investigation·Iddo Z Ben-DovJustin Silver
Mar 17, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Rohit BhuriyaGeorge L Bakris
Apr 1, 2009·Journal of Bone and Mineral Metabolism·David H SmithNancy Neil
Apr 28, 2009·Current Opinion in Nephrology and Hypertension·Minnkyong Lee, Nicola C Partridge
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Oct 20, 2011·Endocrine Research·Guglielmo M TrovatoDaniela Catalano
Mar 19, 2013·International Journal of Epidemiology·Sun-Seog KweonJin-Su Choi

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Citations

Mar 12, 2021·European Journal of Pediatrics·Julie Mouron-HryciukHassib Chehade

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