Parathyroid hormone may maintain bone formation in hibernating black bears (Ursus americanus) to prevent disuse osteoporosis

The Journal of Experimental Biology
Seth W DonahueMeghan E McGee

Abstract

Mechanical unloading of bone causes an imbalance in bone formation and resorption leading to bone loss and increased fracture risk. Black bears (Ursus americanus) are inactive for up to six months during hibernation, yet bone mineral content and strength do not decrease with disuse or aging. To test whether hibernating bears have biological mechanisms to prevent disuse osteoporosis, we measured the serum concentrations of hormones and growth factors involved in bone metabolism and correlated them with the serum concentration of a bone formation marker (osteocalcin). Serum was obtained from black bears over a 7-month duration that included periods of activity and inactivity. Both resorption and formation markers increased during hibernation, suggesting high bone turnover occurred during inactivity. However, bone formation appeared to be balanced with bone resorption. The serum concentration of parathyroid hormone (PTH) was higher in the hibernation (P=0.35) and post-hibernation (P=0.006) seasons relative to pre-hibernation levels. Serum leptin was lower (P<0.004) post-hibernation relative to pre-hibernation and hibernation periods. Insulin-like growth factor I (IGF-I) decreased (P<0.0001) during hibernation relative to pre-hiber...Continue Reading

References

Dec 1, 1977·Journal of Dental Research·A C Haller, M L Zimny
Dec 1, 1979·The Journal of Experimental Zoology·B SteinbergO G Mitchell
Jul 1, 1989·Physiological Reviews·P V HauschkaC M Gundberg
Jan 1, 1989·The Journal of Clinical Investigation·E CanalisT L McCarthy
Sep 1, 1987·Mayo Clinic Proceedings·R A Nelson
Feb 1, 1982·Analytical Biochemistry·P Patterson-AllenP X Callahan
Nov 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D D BikleE R Morey-Holton
Sep 1, 1994·The American Journal of Physiology·P Patterson-BuckendahlC L Ortiz
Jun 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G ColomboH H Malluche
Dec 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A A PitsillidesL E Lanyon
Jul 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B P HalloranE Morey-Holton
Oct 23, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J E ZerwekhC Y Pak
Jan 20, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P J KostenuikD D Bikle
Feb 23, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y MaC Lin
Mar 20, 1999·Archives of Physical Medicine and Rehabilitation·P W NanceD Uebelhart
Nov 26, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J RantakokkoE Vuorio
Aug 24, 2000·Calcified Tissue International·K D Ryder, R L Duncan
Jun 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J M HockD Stanislaus
Sep 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Daniel D BikleBernard P Halloran
Nov 7, 2002·Cell·Shu TakedaGerard Karsenty
Mar 5, 2003·Clinical Orthopaedics and Related Research·Seth W DonahueHenry J Donahue
Mar 7, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J R ZanchettaS L Myers
May 15, 2003·American Journal of Physiology. Endocrinology and Metabolism·Astrid D BakkerElisabeth H Burger
May 16, 2003·Nature·Shun-ichi Harada, Gideon A Rodan
Oct 29, 2003·The Journal of Experimental Biology·Seth W DonahueHenry J Donahue
Oct 31, 2003·Journal of the American Veterinary Medical Association·O Lynne NelsonWilliam F Christensen
Dec 24, 2003·The Journal of Experimental Biology·Nicholas J HudsonCraig E Franklin
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Takeshi SakataDaniel D Bikle
Jun 29, 2004·Journal of Applied Physiology·L C ShackelfordD Lai
Oct 13, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yukiko WatanabeToshitaka Nakamura
Dec 28, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Chao Yang LiMitchell B Schaffler
Jan 20, 2005·Surgery·Jack M Monchik, Emre Gorgun
Feb 23, 2005·Nature·Florent ElefteriouGerard Karsenty
Oct 26, 2005·Joint, Bone, Spine : Revue Du Rhumatisme·Isabelle Legroux-GerotBernard Cortet

❮ Previous
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Citations

Feb 24, 2009·Nutrition and Cancer·Micah MaetaniRobert V Cooney
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·N Kondo
Apr 17, 2009·American Journal of Physiology. Cell Physiology·Yan-Liang ZhangMirianas Chachisvilis
Oct 10, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Meghan E McGee-LawrenceSeth W Donahue
Jun 8, 2010·Thrombosis Journal·Ole FröbertJon M Arnemo
Feb 22, 2014·Integrative and Comparative Biology·Alison H DohertySeth W Donahue
Jun 18, 2015·Clinical and Translational Science·Maria Berg von LindeOle Fröbert
Dec 21, 2012·Kidney International·Peter StenvinkelRichard J Johnson
Jul 2, 2010·British Journal of Pharmacology·Linda K VaughnCecilia J Hillard
Mar 27, 2015·International Journal of Endocrinology·Janina KueperJosh E Schroeder
Oct 28, 2015·Molecular and Cellular Endocrinology·Michaël R LaurentFerran Jardí
Feb 16, 2017·Annual Review of Animal Biosciences·Janice M Bahr
Jan 16, 2018·Nature Reviews. Nephrology·Peter StenvinkelRichard J Johnson
Sep 2, 2016·The Journal of Experimental Biology·Beau D Reilly, Craig E Franklin
Jul 7, 2011·American Journal of Physiology. Endocrinology and Metabolism·Stanley BlumenthalTerry Unterman
Nov 12, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Samantha J WojdaSeth W Donahue
Aug 28, 2020·PloS One·Alireza NasooriToshio Tsubota
Sep 26, 2019·Frontiers in Veterinary Science·Amanda H BoesenJon M Arnemo
Jan 16, 2020·Scientific Reports·Peter Godsk JørgensenOle Fröbert
Jan 4, 2020·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Yasir ArfatCharles H Hocart
Mar 9, 2021·Frontiers in Physiology·Fabrice BertileSylvain Giroud
Apr 17, 2021·Scientific Reports·Anna V GoropashnayaVadim B Fedorov
Apr 5, 2017·The Journal of Experimental Biology·Anne-Mari J MustonenT Petteri Nieminen
Jul 15, 2015·The Journal of Experimental Biology·Meghan McGee-LawrenceSeth Donahue
Jul 24, 2021·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Rongrong YinYunfang Gao

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